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Accelerating the implementation of biocatalysis in industry
1Department of Chemical and Biochemical Engineering, Technical University of Denmark, 2800, Kgs. Lyngby, Denmark. jw@kt.dtu.dk.
Applied Microbiology and Biotechnology
|May 4, 2019
Summary
Biocatalysis in fine chemical production requires further research in areas like machine learning for protein engineering and continuous process technology to realize its full industrial potential.
Area of Science:
- Biotechnology and Bioprocess Engineering
- Chemical Engineering
Background:
- Significant advancements in protein and bioprocess engineering have been made.
- The full potential of biocatalysis in the fine chemical industry remains unrealized.
Purpose of the Study:
- To review the current status of key research areas essential for industrial biocatalysis.
- To identify critical factors hindering the widespread application of biocatalysis in fine chemical synthesis.
Main Methods:
- Mini-review of current research topics.
- Discussion of eight critical areas for biocatalysis implementation.
Main Results:
- Identified eight key research areas requiring further investigation.
- Highlighted the need for advancements in machine learning for protein engineering, mathematical modeling, process standardization, continuous processing, industrial implementation strategies, downstream processing, enzyme stability prediction, and reactor technology.
Conclusions:
- Further research and development in the identified areas are crucial for unlocking the industrial potential of biocatalysis.
- Addressing these challenges will accelerate the adoption of biocatalysis in the fine chemical sector.
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