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Related Experiment Video

Updated: Jan 25, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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[HIS bundle pacing : Far more than an ECG cosmetic effect].

F Al Samaan1, S Hobbiesiefken1, A Reinhardt1

  • 1Elektrophysiologie Bremen, Zentrum im Herzzentrum Klinikum Links der Weser, Senator-Weßling-Str. 1, 28277, Bremen, Deutschland.

Herzschrittmachertherapie & Elektrophysiologie
|May 4, 2019
PubMed
Summary

Heart failure with preserved ejection fraction (HFpEF) lacks effective treatments, especially when patients also have atrioventricular (AV) block. His bundle pacing offers a hopeful strategy by enabling AV resynchronization in these challenging cases.

Keywords:
AV blockAV resynchronizationDiastolic dysfunctionHFpEFPacemaker

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Area of Science:

  • Cardiology
  • Electrophysiology
  • Heart Failure Research

Background:

  • Therapy for heart failure with preserved ejection fraction (HFpEF) remains challenging due to limited effective treatment options.
  • A subset of HFpEF patients present with concomitant atrioventricular (AV) block, complicating management.
  • Existing therapeutic strategies for HFpEF do not adequately address the needs of patients with AV block.

Purpose of the Study:

  • To investigate the potential of His bundle pacing as a therapeutic strategy for HFpEF patients with AV block.
  • To evaluate the feasibility and efficacy of His bundle pacing in achieving AV resynchronization in this specific patient population.
  • To present a case study illustrating the benefits of His bundle pacing in managing HFpEF with AV block.

Main Methods:

  • This study focuses on a case report detailing the application of His bundle pacing.
  • The methodology involves assessing the ability of His bundle pacing to achieve atrioventricular resynchronization.
  • Diagnostic and therapeutic interventions were guided by electrophysiological principles.

Main Results:

  • His bundle pacing demonstrated potential as a viable treatment option for HFpEF patients experiencing AV block.
  • Successful AV resynchronization was achieved through His bundle pacing, as evidenced in the case presented.
  • This approach offers a novel therapeutic avenue for a challenging clinical scenario.

Conclusions:

  • His bundle pacing emerges as a promising therapeutic strategy for heart failure with preserved ejection fraction patients who also have atrioventricular block.
  • The capacity for AV resynchronization makes His bundle pacing a hopeful option where conventional therapies are insufficient.
  • Further research and case studies are warranted to fully elucidate the role of His bundle pacing in HFpEF management.