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Delivery of therapeutic miRNA using polymer-based formulation
Eunmi Ban1, Taek-Hyun Kwon1, Aeri Kim2
1College of Pharmacy, CHA University, 521 CHA Bio Complex, 335 Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13488, South Korea.
Drug Delivery and Translational Research
|May 4, 2019
Summary
MicroRNAs (miRNAs) are crucial for cellular processes but face delivery challenges. Polymer-based carriers show promise for enhancing miRNA therapeutics, potentially accelerating clinical development.
Area of Science:
- Biochemistry
- Molecular Biology
- Biotechnology
Background:
- MicroRNAs (miRNAs) regulate key cellular functions like development and apoptosis.
- miRNAs are explored as biomarkers and therapeutics for diseases including cancer and cardiovascular conditions.
- Effective delivery of miRNAs and antagomirs is hindered by poor cellular uptake and nuclease degradation.
Purpose of the Study:
- To review polymer-based delivery systems for microRNAs (miRNAs) and their antagomirs.
- To discuss the properties and applications of specific polymeric carriers for miRNA delivery.
- To highlight the potential of polymeric systems in advancing miRNA therapeutics.
Main Methods:
- Review of existing literature on polymer-based miRNA delivery systems.
- Analysis of properties of poly (lactic-co-glycolic acid), chitosan, polyethyleneimine, and polyamidoamine dendrimers.
- Examination of current clinical trial approaches for miRNA therapeutics.
Main Results:
- Non-viral, polymer-based carriers offer versatile structural modifications and protect unstable miRNAs.
- Polymeric carriers demonstrate advantages for delivering miRNA mimics or antagomirs.
- Most current clinical trials utilize chemically modified miRNAs, with limited use of delivery systems like liposomes.
Conclusions:
- Polymer-based delivery systems are effective for enhancing miRNA delivery to target sites.
- Continued research in polymeric miRNA delivery is expected to accelerate clinical translation.
- Polymeric delivery systems hold significant potential for the future of miRNA-based therapeutics.
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