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Delivery of therapeutic miRNA using polymer-based formulation

Eunmi Ban1, Taek-Hyun Kwon1, Aeri Kim2

  • 1College of Pharmacy, CHA University, 521 CHA Bio Complex, 335 Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13488, South Korea.

Drug Delivery and Translational Research
|May 4, 2019
PubMed

Insights

MicroRNAs (miRNAs) are crucial for cellular processes but face delivery challenges. Polymer-based carriers show promise for enhancing miRNA therapeutics, potentially accelerating clinical development.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Biotechnology

Background:

  • MicroRNAs (miRNAs) regulate key cellular functions like development and apoptosis.
  • miRNAs are explored as biomarkers and therapeutics for diseases including cancer and cardiovascular conditions.
  • Effective delivery of miRNAs and antagomirs is hindered by poor cellular uptake and nuclease degradation.

Purpose of the Study:

  • To review polymer-based delivery systems for microRNAs (miRNAs) and their antagomirs.
  • To discuss the properties and applications of specific polymeric carriers for miRNA delivery.
  • To highlight the potential of polymeric systems in advancing miRNA therapeutics.

Main Methods:

  • Review of existing literature on polymer-based miRNA delivery systems.
  • Analysis of properties of poly (lactic-co-glycolic acid), chitosan, polyethyleneimine, and polyamidoamine dendrimers.
  • Examination of current clinical trial approaches for miRNA therapeutics.

Main Results:

  • Non-viral, polymer-based carriers offer versatile structural modifications and protect unstable miRNAs.
  • Polymeric carriers demonstrate advantages for delivering miRNA mimics or antagomirs.
  • Most current clinical trials utilize chemically modified miRNAs, with limited use of delivery systems like liposomes.

Conclusions:

  • Polymer-based delivery systems are effective for enhancing miRNA delivery to target sites.
  • Continued research in polymeric miRNA delivery is expected to accelerate clinical translation.
  • Polymeric delivery systems hold significant potential for the future of miRNA-based therapeutics.
Keywords:
Anti-miRNAsFormulationMicroRNA deliveryPolymermiRNA mimic

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