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Changing our microbiome: probiotics in dermatology
1Department of Dermatology, University of Cincinnati, Cincinnati, OH, U.S.A.
The British Journal of Dermatology
|May 4, 2019
Summary
Probiotics show promise for treating inflammatory skin conditions and aiding wound healing. Further research is needed to confirm the effectiveness of oral and topical probiotics in dermatology.
Area of Science:
- Microbiology
- Dermatology
- Immunology
Background:
- Commensal bacteria significantly influence human health and disease.
- Research interest is expanding from the gut microbiome to the skin microbiome's role in dermatological conditions.
Purpose of the Study:
- To review current data on the microbiome's role in dermatology.
- To evaluate clinical evidence supporting oral and topical probiotics for skin diseases.
Main Methods:
- Searched PubMed and ClinicalTrials.gov for relevant studies.
- Included basic science, translational, and clinical research.
- Focused on atopic dermatitis, acne, psoriasis, wounds, seborrheic dermatitis, and skin neoplasms.
Main Results:
- Limited clinical trials exist, particularly for prevention and treatment, except for atopic dermatitis.
- Most studies used oral probiotics; few topical probiotic studies included skin commensals.
- Overall, clinical trials showed positive outcomes, with skin condition improvements after probiotic intervention.
Conclusions:
- Oral and topical probiotics show potential for inflammatory skin diseases, wound healing, and skin cancer treatment.
- More research is necessary to validate these findings.
- This review synthesizes current data and proposes future probiotic research directions in dermatology.
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