Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Criteria for Causality: Bradford Hill Criteria - II01:28

Criteria for Causality: Bradford Hill Criteria - II

1.2K
The Bradford Hill criteria serve as guidelines for establishing causative links in epidemiological research. Beyond Strength, Consistency, Specificity, and Temporality, key criteria also include Biological Gradient, Plausibility, Coherence, Experiment, and Analogy. These principles assist scientists in assessing the likelihood of causation in complex biological contexts. Below is a summary of these concepts:
1.2K
Criteria for Causality: Bradford Hill Criteria - I01:30

Criteria for Causality: Bradford Hill Criteria - I

1.1K
The Bradford Hill criteria are a group of principles that provide a framework to determine a causal relationship between a specific factor and a disease. There are nine criteria that are pivotal in assessing causality in epidemiological studies. Here's a closer look at Strength, Consistency, Specificity, and Temporality criteria with definitions and examples:
1.1K
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

662
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
662
Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

775
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
775
Classification of Neurotransmitters01:30

Classification of Neurotransmitters

5.2K
Neurotransmitters play a crucial role in the communication between neurons in the autonomic nervous system. Neurons in the autonomic nervous system can be cholinergic or adrenergic depending on the neurotransmitters synthesized. Cholinergic neurons use acetylcholine as their primary neurotransmitter. This includes all the preganglionic fibers of the sympathetic and pre- and postganglionic fibers of the parasympathetic nervous systems. In addition, neurons of the somatic nervous system also use...
5.2K
Classification of Leukocytes01:30

Classification of Leukocytes

5.3K
Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
5.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Qualitative interview study in patients with SLE to assess patient perception of fatigue and skin-related symptoms.

Lupus science & medicine·2026
Same author

Rapid Onset of Response in Adults with Dermatomyositis Receiving Dazukibart: A Phase 2, Double-Blind, Randomized, Placebo-Controlled Study.

Clinical, cosmetic and investigational dermatology·2026
Same author

HKD-MGIN: a physics informed graph neural network using heat kernel diffusion for mapping adolescent functional brain connectivity.

Machine learning for computational science and engineering·2026
Same author

Reply.

Arthritis & rheumatology (Hoboken, N.J.)·2026
Same author

Therapeutic Approaches for Cutaneous Lupus Erythematosus: a Changing Landscape of Clinical Trials.

Journal of inflammation research·2026
Same author

Identifying immunostimulatory herbal supplements that may flare autoimmune skin diseases: a systematic scoping review.

Lupus science & medicine·2025

Related Experiment Video

Updated: Jan 25, 2026

Development of an Economical DNA Delivery System by "Acufection" and its Application to Skin Research
09:42

Development of an Economical DNA Delivery System by "Acufection" and its Application to Skin Research

Published on: April 19, 2017

7.9K

Developing classification criteria for skin-predominant dermatomyositis: the Delphi process.

J S S Concha1,2, S Pena1,2, R G Gaffney1,2

  • 1Michael J. Crescenz VAMC, Philadelphia, PA, U.S.A.

The British Journal of Dermatology
|May 4, 2019
PubMed
Summary

New classification criteria for skin-predominant dermatomyositis (DM) are being developed. A list of 25 potential criteria was generated by experts to improve patient classification for clinical research.

More Related Videos

Horizontal Whole Mount: A Novel Processing and Imaging Protocol for Thick, Three-dimensional Tissue Cross-sections of Skin
08:31

Horizontal Whole Mount: A Novel Processing and Imaging Protocol for Thick, Three-dimensional Tissue Cross-sections of Skin

Published on: August 2, 2017

15.8K
Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay
07:40

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay

Published on: April 28, 2022

3.3K

Related Experiment Videos

Last Updated: Jan 25, 2026

Development of an Economical DNA Delivery System by "Acufection" and its Application to Skin Research
09:42

Development of an Economical DNA Delivery System by "Acufection" and its Application to Skin Research

Published on: April 19, 2017

7.9K
Horizontal Whole Mount: A Novel Processing and Imaging Protocol for Thick, Three-dimensional Tissue Cross-sections of Skin
08:31

Horizontal Whole Mount: A Novel Processing and Imaging Protocol for Thick, Three-dimensional Tissue Cross-sections of Skin

Published on: August 2, 2017

15.8K
Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay
07:40

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay

Published on: April 28, 2022

3.3K

Area of Science:

  • Rheumatology
  • Dermatology
  • Clinical Classification

Background:

  • Existing European League Against Rheumatism/American College of Rheumatology criteria inadequately classify all patients with skin-predominant dermatomyositis (DM).
  • Approximately 25% of patients with skin-predominant DM do not meet current classification criteria.
  • There is a need for more inclusive criteria for clinical research.

Purpose of the Study:

  • To develop novel, skin-focused classification criteria for cutaneous dermatomyositis (DM).
  • To distinguish skin-predominant DM from conditions with similar presentations (mimickers).
  • To establish a more inclusive definition for skin-predominant DM in research settings.

Main Methods:

  • An international Delphi consensus process involving 50 dermatologists and rheumatologists.
  • Literature review to generate initial items, followed by two rounds of expert rating and consensus.
  • Items were categorized by distribution, morphology, symptoms, antibodies, histology, and contextual factors.

Main Results:

  • A list of 25 potential classification criteria items was generated.
  • Items were refined through expert consensus, with a cut-off score of 80 in the second round.
  • The process involved participants from North America, South America, Europe, and Asia.

Conclusions:

  • This Delphi project successfully generated a list of potential classification criteria for skin-predominant DM.
  • These criteria aim to improve the classification of patients for clinical and translational research.
  • This work is a crucial step towards developing prospectively validated classification criteria for DM.