Related Experiment Video
Updated: Jan 25, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Concurrent training performed with and without repetitions to failure in older men: A randomized clinical trial
Juliana L Teodoro1, Larissa X Neves da Silva1, Carolina G Fritsch2
1School of Physical Education, Physiotherapy and Dance, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Abstract:
This study compared the effects of 20 weeks of concurrent training with and without repetitions to failure on neuromuscular and functional adaptations in older men.
Methods:
Thirty-six older men (67.1 ± 5.1 years) were randomized into three groups: one performing repetitions to failure (RFG, n = 13), another performing repetitions not to failure and 50% of the repetitions of the RFG (NFG, n = 12), and a third performing repetitions not to failure with equal training volume of the RFG (ENFG, n = 11). Training was performed twice a week for 20 weeks at intensities ranging from 65% to 80% of maximal strength. In each session, the individuals started with strengthening exercises and then performed aerobic exercise on a treadmill. Before and after the intervention, individuals were assessed for their one repetition maximum (1RM) for leg press (LP) and knee extension (KE) exercises, knee extensors' isometric peak torque (PTiso ), and rate of torque development (RTD) at 50 ms, 100 ms, and 250 ms, muscle thickness of the quadriceps, as well as functional performance on sit-to-stand, and timed up and go tests.
Results:
After training, there were significant (P < 0.001) increases in the LP and KE 1RM, PTiso , and RTD outcomes in all groups. Also, there were significant increases in muscle thickness of the quadriceps and in the sit-to-stand test (P < 0.05) in all groups. No significant differences were observed between groups in any outcome.
Conclusion:
Concurrent training using repetitions to concentric failure did not promote additional benefits for neuromuscular function, muscle thickness, or functional capacity of older individuals.
Related Concept Videos
Clinical Trials
There are four phases in a clinical trial. A phase one...
Clinical Trials: Overview
Statistical Software for Data Analysis and Clinical Trials
Heart Failure III: Clinical Manifestations
Trial and Error and Algorithm
Random Error

