Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Trials01:16

Clinical Trials

10.2K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
10.2K
Clinical Trials: Overview01:11

Clinical Trials: Overview

4.7K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.7K
Statistical Software for Data Analysis and Clinical Trials01:12

Statistical Software for Data Analysis and Clinical Trials

1.4K
Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
1.4K
Hypersensitivities01:30

Hypersensitivities

7.3K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
7.3K
Trial and Error and Algorithm01:12

Trial and Error and Algorithm

403
A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
403
Random Error01:04

Random Error

9.2K
Random or indeterminate errors originate from various uncontrollable variables, such as variations in environmental conditions, instrument imperfections, or the inherent variability of the phenomena being measured. Usually, these errors cannot be predicted, estimated, or characterized because their direction and magnitude often vary in magnitude and direction even during consecutive measurements. As a result, they are difficult to eliminate. However, the aggregate effect of these errors can be...
9.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Influence of polishing methods on the physical properties of temporary restorations.

Odontology·2025
Same author

Influence of occlusal loading type and cyclic fatigue on the mechanical behavior of sound maxillary premolars: a laboratory and 3D finite element analysis.

Brazilian dental journal·2025
Same author

Mechanical behavior of hybrid custom implant abutments with various crown materials: a 3D finite element analysis.

BMC oral health·2025
Same author

Effect of Brazilian green and brown propolis on human pulp cells and bacteria involved in primary endodontic infection: Ex Vivo study.

Archives of oral biology·2025
Same author

Multidisciplinary Oral Rehabilitation in a Patient With Dental Anomaly: A Case Report With 18-Month Follow-Up.

Case reports in dentistry·2025
Same author

Association between non-carious cervical lesions, dentin hypersensitivity and anxiety in young adults: A cross-sectional study.

Journal of dentistry·2025

Related Experiment Video

Updated: Jan 25, 2026

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
03:26

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain

Published on: March 8, 2024

3.5K

Four-Session Protocol Effectiveness in Reducing Cervical Dentin Hypersensitivity: A 24-Week Randomized Clinical

Guilherme Faria Moura1, Lívia Fávaro Zeola1, Michele Borges Silva1

  • 1NCCL Research Group, Department of Operative Dentistry and Dental Materials, School of Dentistry, Federal University of Uberlândia, Uberlândia, Brazil.

Photobiomodulation, Photomedicine, and Laser Surgery
|May 4, 2019
PubMed
Summary

This study found that four sessions of desensitizing treatments effectively reduced cervical dentin hypersensitivity (CDH) for 24 weeks. All tested agents, including Desensibilize KF 2%, Clinpro XT Varnish, and laser therapy, showed comparable results in managing CDH.

Keywords:
GaAlAs lasersclinical researchdentinlasers in dentistrylow-power laser irradiationpainprotocol

More Related Videos

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
03:53

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management

Published on: March 15, 2024

3.0K
Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
06:13

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health

Published on: December 1, 2023

1.6K

Related Experiment Videos

Last Updated: Jan 25, 2026

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
03:26

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain

Published on: March 8, 2024

3.5K
Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
03:53

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management

Published on: March 15, 2024

3.0K
Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
06:13

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health

Published on: December 1, 2023

1.6K

Area of Science:

  • Dentistry
  • Dental Therapeutics
  • Pain Management

Background:

  • Cervical dentin hypersensitivity (CDH) affects a significant portion of the population.
  • Various desensitizing agents with different mechanisms exist, but their comparative effectiveness requires further investigation.
  • Standardized treatment protocols are crucial for managing CDH.

Purpose of the Study:

  • To evaluate and compare the effectiveness of desensitizing agents with distinct action mechanisms in reducing CDH.
  • To assess the long-term efficacy of a four-application session protocol for CDH management.
  • To determine if the mechanism of action influences treatment outcomes for CDH.

Main Methods:

  • A single-blind randomized clinical trial involving 60 patients with CDH.
  • Three treatment groups: Desensibilize KF 2%, Clinpro XT Varnish, and Photon Lase III (808 nm laser).
  • Four application sessions with 48-hour intervals, followed by evaluations at baseline, post-treatment, and at 2, 4, 8, and 24 weeks using evaporative stimuli and a visual analog scale.

Main Results:

  • All three treatment groups demonstrated a significant reduction in CDH from baseline across all follow-up points.
  • No statistically significant differences in CDH reduction were observed among the groups at any follow-up interval (p > 0.05).
  • The observed reduction in CDH was sustained up to 24 weeks post-treatment.

Conclusions:

  • A four-session treatment protocol is effective in reducing cervical dentin hypersensitivity.
  • The effectiveness of CDH reduction is maintained for at least 24 weeks, irrespective of the desensitizing agent's mechanism of action.
  • Clinicians can achieve comparable CDH reduction using different desensitizing modalities within this protocol.