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The state of oxidative homeostasis in children with influenza stomatitis
Nataliia O Gevkaliuk1, Nataliya I Sydliaruk1, Larysa Ya Posolenyk1
1State Institution Of Higher Education "I. Horbachevsky Ternopil State Medical University", Ternopil, Ukraine.
Insights
Children with influenza stomatitis exhibit heightened lipid peroxidation and an impaired antioxidant system, contributing to intoxication. This study investigated oxidative homeostasis in pediatric influenza stomatitis.
Area of Science:
- Pediatric infectious diseases
- Biochemistry
- Immunology
Background:
- Acute respiratory viral infections (ARVIs) and their clinical course, particularly in children with influenza stomatitis, require further investigation.
- The role of oxidative homeostasis in non-specific resistance during pediatric influenza stomatitis is not well-understood.
Purpose of the Study:
- To characterize the oxidative-prooxidant system in children diagnosed with influenza stomatitis.
- To assess the relationship between oxidative homeostasis and disease severity in pediatric influenza stomatitis.
Main Methods:
- A cohort of 384 children (6 months to 12 years) with ARVIs, including 318 with oral cavity lesions, were studied.
- Lipid peroxidation was assessed via spectrophotometric determination of diene conjugates.
- Ceruloplasmin activity and transferrin saturation by iron were measured using established methods.
Main Results:
- Significant intensification of lipid peroxidation was observed, with increased diene conjugates correlating with disease severity.
- Ceruloplasmin activity elevated 1.8-fold in severe cases.
- Transferrin saturation by iron significantly decreased by 15.27% in severe influenza stomatitis.
Conclusions:
- Changes in the antioxidant system are linked to activated lipid peroxidation in pediatric influenza stomatitis.
- The inability to neutralize toxic metabolites contributes to the development of intoxication syndrome.
- These findings highlight the critical role of oxidative stress in the pathophysiology of influenza stomatitis in children.
Objective:
Introduction: The clinical course of acute respiratory viral infections was not sufficiently studied, specially the state of oxidative homeostasis in children with influenza stomatitis. This fact became the base for our study. The aim: to characterize the state of oxidative-prooxidant system as one of the factors of non-specific resistance of children` organism with influenza stomatitis.
Patients And Methods:
Materials and methods: A survey was conducted on 384 children with acute respiratory viral infections aged from 6 months to 12 years, among them 318 had lesions of oral cavity. The mild form was diagnosed in 52 children, moderately severe - in 185, severe - in 81 children. The control group consisted of children without lesions of oral cavity (66 people). To analyze lipid peroxidation we used a spectrophotometric determination of diene conjugates. The ceruloplasmin activity and the transferrin saturation in blood plasma by iron were determined by G. Babenko's method.
Results:
Results: We found the intensification of lipid peroxidation: a significant increase of diene conjugates in serum up to 13.78 %, the level of which depended on the severity of disease. We also found the activity increase of ceruloplasmin in 1,8 times in patients with severe course of disease. The saturation of blood plasma transferrin by iron was significantly reduced - for 15.27 % in patients with severe course of influenza stomatitis.
Conclusion:
Conclusions: Changes in antioxidant system happend due to the activation of lipid peroxidation, and because of the inability to neutralize toxic metabolites in the children` body the intoxication syndrome developed.
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