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Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials
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Synthetic genetic circuits for programmable biological functionalities.

Peng-Fei Xia1, Hua Ling1, Jee Loon Foo1

  • 1Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore; NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore.

Biotechnology Advances
|May 4, 2019
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Summary
This summary is machine-generated.

Synthetic biology enables the creation of genetic circuits from modular parts. These circuits allow for programmable functions in microorganisms, leading to diverse applications in biotechnology and bioengineering.

Keywords:
Genetic circuitsGenetic devicesProgrammable functionalities

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Area of Science:

  • Synthetic biology
  • Genetic engineering
  • Biotechnology

Background:

  • Living organisms possess complex genetic networks for environmental interaction.
  • Synthetic biology has identified modular genetic parts for constructing synthetic genetic circuits.
  • These circuits include toggle switches, oscillators, feedback loops, and Boolean logic gates.

Purpose of the Study:

  • To outline principles in genetic circuit design for realistic applications.
  • To discuss features of modular building blocks and circuit architecture.
  • To highlight advances and challenges in employing genetic circuits for programmable microbial functionalities.

Main Methods:

  • Review of principles in genetic circuit design.
  • Analysis of modular genetic parts and circuit architecture.
  • Discussion of recent advances and challenges in synthetic genetic circuits.

Main Results:

  • Genetic circuits can be constructed using modular parts for programmable decision-making.
  • Applications include metabolic network modulation, directed evolution, diagnostics, therapies, and biological containment.
  • Design principles and architectural features facilitate circuit realization for novel applications.

Conclusions:

  • Synthetic genetic circuits represent a new chapter in transforming biological concepts into applications.
  • Further insights into design and implementation guidelines for biotechnology and bioengineering are provided.
  • Genetic circuits offer a pathway to impart distinct and programmable functionalities to microorganisms.