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Related Experiment Video

Updated: Jan 25, 2026

Simple and Rapid Method to Obtain High-quality Tumor DNA from Clinical-pathological Specimens Using Touch Imprint Cytology
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Maximizing derivable information from cytologic specimens for pathologic and molecular diagnostics.

Wilfrido D Mojica1, Kwang W Oh2, Hun Lee2

  • 1Department of Pathology and Anatomical Sciences, University at Buffalo, The State University of New York, 100 High Street, Buffalo, New York.

Journal of the American Society of Cytopathology
|May 5, 2019
PubMed
Summary
This summary is machine-generated.

Microfluidics allows obtaining both cytologic and molecular data from the same cells in patient tumor samples. This multiplex testing approach is ideal for precious, paucicellular specimens requiring molecular diagnostics.

Keywords:
CytologyHigh-molecular weight DNAMicrofluidicsMolecular testingPolymerase chain reaction

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Area of Science:

  • Biomedical Engineering
  • Molecular Diagnostics
  • Cytopathology

Background:

  • Precision medicine drives demand for molecular testing of patient tumor specimens.
  • Cytology samples are suitable for molecular testing but often paucicellular.
  • Paucicellular samples pose challenges for sample management and multiplex testing.

Purpose of the Study:

  • Investigate a microfluidic platform for simultaneous cytologic and molecular analysis.
  • Determine if cytologic and molecular data can be obtained from the same cells.
  • Obviate sample partitioning by multiplexing on a microfluidic device.

Main Methods:

  • Cytology samples were prepared, stained, and enriched with immunomagnetic beads.
  • Cells and beads traversed a microfluidic channel for temporary immobilization and cytologic examination.
  • Recovered cells underwent DNA extraction and integrity assessment; cytologic features were compared to conventional methods.

Main Results:

  • Cytologic features of microfluidic-processed cells were comparable to conventionally prepared cells.
  • High molecular weight DNA was successfully recovered from cells processed through the microfluidic channel.

Conclusions:

  • Microfluidics enables multiplex testing of cytologic specimens.
  • This platform facilitates both cytology-based diagnostics and high-quality DNA recovery.
  • The approach is particularly beneficial for paucicellular specimens needing molecular testing.