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Updated: Jan 25, 2026
03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
772
Squamous cells in effusions: A study of 24 cases
Laura J Adhikari1, Camille T Elkins1, Paul E Wakely1
1Department of Pathology, Wexner Medical Center at The Ohio State University, Columbus, Ohio.
Journal of the American Society of Cytopathology
|May 5, 2019
Summary
Malignant squamous cells in serous effusions, particularly squamous cell carcinoma (SqCC), are rare and associated with a poor prognosis. This study analyzed 21 effusion specimens, finding metastatic SqCC in 19 cases.
Area of Science:
- Cytopathology
- Oncology
- Fluid analysis
Background:
- Malignant squamous cells in serous effusions are infrequently encountered.
- Squamous cell carcinoma (SqCC) diagnosis in effusions presents diagnostic challenges.
Purpose of the Study:
- To review the experience with squamous cell carcinoma (SqCC) and benign squamous cells in serous effusions.
- To characterize the cytomorphological features and clinical outcomes of SqCC in effusions.
Main Methods:
- Retrospective review of serous effusion specimens with
- squamous
- in the final diagnosis.
- Analysis of 21 confirmed cases (19 SqCC, 2 benign squamous cells).
Main Results:
- SqCC was identified in 19 of 21 analyzed effusion specimens (76% pleural fluid).
- Common SqCC cell types included round-oval with dense cytoplasm (n=12) and undifferentiated cells (n=4).
- Features like refractile rings (89%), keratin pearls (53%), and keratinization (63%) were noted in SqCC cases. All SqCC patients had a poor prognosis with a mean survival of 58.1 days.
Conclusions:
- Metastatic squamous cell carcinoma (SqCC) in serous effusions is rare.
- SqCC in effusions typically presents as single cells with specific cytomorphological features.
- The presence of metastatic SqCC in effusions indicates a dismal prognosis.
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