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Updated: Jan 13, 2026

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
Published on: June 14, 2019
Human Papillomavirus-related Oropharyngeal Carcinoma: Current Understanding and Enduring Uncertainties
Shao Hui Huang1, Tara Rosewall1
1University of Toronto/Princess Margaret Hospital, Toronto, Ontario, Canada.
Abstract:
The etiological role of high risk human papillomavirus (HPV) has been widely accepted in carcinomas of cervix, but this has only recently been confirmed in a subset of oropharyngeal carcinomas (OPC). The HPV-related OPC has now been clinically differentiated from the classic smoking/drinking-related OPC, and is considered a distinct molecular and clinical entity. This literature review aims to provide a summary of the current understanding and enduring uncertainties in the field of HPV-related OPC, specifically related to: the natural history and carcinogenic effect of HPV infection, the clinicopathology and treatment response of HPV-related OPC, and broader HPV-related social and medico-ethical issues.
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