Development of a Spherical Model with a 3D Microchannel: An Application to Glaucoma Surgery

Area of Science:

• Biomedical Engineering
• Ophthalmology
• Surgical Simulation

Background:

• Current surgical simulators lack realistic anatomical and mechanical properties of human tissues.
• Existing models do not adequately mimic human eye structures for surgical training.

Purpose of the Study:

• To develop a novel, anatomically accurate eye model for glaucoma surgery simulation.
• To create a training tool that replicates human tissue properties for novice surgeons.

Main Methods:

• Fabricated a 3D microfluidic eye model using 3D molding and blow molding techniques.
• Integrated a 3D microchannel (200-500 µm width) for Schlemm's canal (SC) and a thin membrane (40-132 µm thickness) for trabecular meshwork (TM).
• Utilized soft materials with controllable mechanical properties to mimic human ocular tissues.

Main Results:

• Successfully created an eye model with a clear cornea, sclera, SC microchannel, and TM membrane.
• The model's materials mimic the mechanical behavior of human tissues.
• The eye model was mounted on a skull platform to simulate surgical constraints.

Conclusions:

• The proposed fabrication method enables the creation of a realistic eye model for glaucoma surgery training.
• This novel simulator provides a valuable tool for evaluating surgical devices and training surgeons.
• The integrated 3D microchannel and membrane accurately represent key anatomical structures for glaucoma surgery practice.