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Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
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Focus on Formononetin: Anticancer Potential and Molecular Targets
Samantha Kah Ling Ong1, Muthu K Shanmugam2, Lu Fan3
1Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore. samantha.ong@u.nus.edu.
Cancers
|May 5, 2019
Summary
Formononetin, a plant-derived isoflavone, shows promise as an anticancer agent by promoting apoptosis and inhibiting cancer cell proliferation. Its antioxidant and neuroprotective effects also suggest therapeutic potential for Alzheimer's disease.
Area of Science:
- Phytochemistry
- Pharmacology
- Oncology
Background:
- Formononetin is an isoflavone found in medicinal plants like red clover and Astragalus membranaceus.
- It exhibits antioxidant and neuroprotective properties, indicating potential for Alzheimer's disease treatment.
- Formononetin is being investigated for its anticancer effects against various cancers.
Purpose of the Study:
- To review and analyze the therapeutic potential of formononetin for malignancies.
- To highlight its molecular targets and anticancer mechanisms.
Main Methods:
- Literature review of current evidence on formononetin's anticancer properties.
- Analysis of in vitro and in vivo studies on cancer cell models.
- Examination of formononetin's effects on molecular pathways and transcription factors.
Main Results:
- Formononetin demonstrates anticancer properties by promoting apoptosis and inhibiting proliferation in breast, colorectal, and prostate cancer models.
- It attenuates tumor growth and metastasis in vivo.
- Its mechanisms involve antiproliferative effects, cell cycle arrest, and regulation of oncogenic pathways.
Conclusions:
- Formononetin shows significant therapeutic potential for various cancers due to its molecular targets and anticancer activities.
- It may help overcome cancer cell resistance to chemotherapy by alleviating chronic inflammation.
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