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Biomaterials for Cleft Lip and Palate Regeneration
Marcela Martín-Del-Campo1,2, Raúl Rosales-Ibañez3, Luis Rojo4,5
1Facultad de Estomatología, Universidad Autónoma de San Luis Potosí, Av. Dr. Salvador Nava No. 2, Zona Universitaria, San Luis Potosí (S.L.P.) 78290, Mexico. mar_tin53@hotmail.com.
International Journal of Molecular Sciences
|May 5, 2019
Summary
Tissue engineering offers new hope for craniofacial bone defects, particularly cleft lip and palate. This review analyzes advanced biomaterials and cell therapies for bone regeneration in these conditions.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Craniofacial Surgery
Background:
- Craniofacial bone defects, including cleft lip and palate, result from trauma, tumors, or congenital disorders, impacting function and appearance.
- Cleft lip and palate are the most common congenital craniofacial defects, causing significant challenges in speech, eating, breathing, and psychosocial well-being.
Purpose of the Study:
- To provide an updated analysis of tissue engineering strategies for cleft lip and palate regeneration.
- To review the application of advanced biomaterials and cell therapies in addressing craniofacial bone defects.
Main Methods:
- Review of current literature on tissue engineering for craniofacial bone regeneration.
- Analysis of studies utilizing 3D biomaterials, osteo-inductive molecules, and stem cells for bone repair.
Main Results:
- Regenerative medicine shows promise for craniofacial bone defect treatment.
- Limited studies have focused on tissue engineering for cleft lip and palate, with few offering clinical solutions.
Conclusions:
- Advanced biomaterials and cell therapies are key to bone regeneration in craniofacial defects.
- Further research is needed to translate tissue engineering advancements into effective clinical treatments for cleft lip and palate.
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