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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

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The Continuing Threat of Methicillin-Resistant Staphylococcus aureus

Márió Gajdács1

  • 1Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, 6720 Szeged, Hungary. gajdacs.mario@pharm.u-szeged.hu.

Antibiotics (Basel, Switzerland)
|May 5, 2019
PubMed

Insights

Methicillin-resistant Staphylococcus aureus (MRSA) is a persistent pathogen causing diverse infections. This review details MRSA

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Staphylococcus aureus is a highly adaptable pathogen responsible for numerous infections.
  • Methicillin-resistant S. aureus (MRSA), identified in 1961, exhibits resistance to beta-lactam antibiotics due to altered penicillin-binding protein (PBP2a/c).
  • MRSA represents a significant challenge as a multidrug-resistant bacterium, complicating treatment and eradication efforts.

Purpose of the Study:

  • To provide a comprehensive review of MRSA, covering its history, emergence, and clinical manifestations.
  • To summarize current advancements in MRSA screening, typing methodologies, and therapeutic strategies.
  • To offer insights for clinical microbiologists and infectious disease specialists regarding MRSA management.

Main Methods:

  • Literature review based on 230 references.
  • Synthesis of historical data on MRSA emergence and evolution.
  • Compilation of current knowledge on MRSA epidemiology, diagnostics, and treatment.

Main Results:

  • MRSA infections are categorized into hospital-, community-, and livestock-associated types.
  • Current therapeutic options include lipoglycopeptides, oxazolidinones, specific cephalosporins, and other agents like daptomycin and fusidic acid.
  • Novel drug candidates are under development to combat MRSA resistance.

Conclusions:

  • MRSA remains a critical global health threat due to its adaptability and resistance.
  • Effective screening, typing, and a range of therapeutic options are essential for managing MRSA infections.
  • Ongoing research into new antimicrobial agents is crucial for future treatment strategies against MRSA.
Keywords:
MRSASSCmecStaphylococcusceftarolinecolonizationdaptomycinlipoglycopeptidesoxazolidinonespleuromutilintyping

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