Related Experiment Video
Updated: Jan 25, 2026
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Sequential In vivo Imaging of Osteogenic Stem/Progenitor Cells During Fracture Repair
Published on: May 23, 2014
11.1K
Osteogenic Cell Behavior on Titanium Surfaces in Hard Tissue.
Jung-Yoo Choi1, Tomas Albrektsson2,3, Young-Jun Jeon4
1Dental Research Institute, Seoul National University, Seoul 03080, Korea. jychoi55@snu.ac.kr.
Journal of Clinical Medicine
|May 5, 2019
Summary
Understanding cellular events during dental implant bone formation is key. This study reveals distinct in vivo cell responses to different implant surfaces using advanced electron microscopy, aiding future implant design.
Area of Science:
- Biomaterials Science
- Cell Biology
- Dental Implantology
Background:
- Visualizing bone formation and cellular events around dental implants in vivo is challenging.
- Osteogenesis occurs differently on smooth (distance) versus roughened (contact) implant surfaces.
- Previous in vitro studies used simplified models, lacking in vivo relevance for actual 3D implants.
Purpose of the Study:
- To investigate in vivo cellular responses to different three-dimensional (3D) dental titanium (Ti) implant surfaces.
- To analyze cell behavior and bone formation at the electron microscopic level on actual implant structures.
- To compare cellular interactions on turned versus roughened implant surfaces in a rabbit tibia model.
Main Methods:
- Utilized an in vivo rabbit tibia model with inserted dental Ti implants.
- Employed advanced electron microscopy techniques: SEM, IF, TEM, FIB-Cs-STEM, and CLSM.
- Analyzed implant surface characteristics and identified cells on different implant structural parts.
Main Results:
- Demonstrated distinct in vivo cell attachment patterns on turned and roughened implant surfaces.
- Revealed specific cellular responses to different implant surface topographies and components.
- Provided electron microscopic evidence of cell behavior during bone regeneration around 3D implants.
Conclusions:
- Electron microscopy offers valuable insights into in vivo cellular responses to 3D dental implants.
- Understanding surface-specific cell behavior can guide the design of improved dental implant surfaces.
- This study provides a foundation for using advanced microscopy in dental implant research.
Keywords:
bone-implant interfacecell plasticitydental implantselectron microscopyosteogenesisscanning transmission electron microscopyMore Related Videos
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