Related Experiment Video
Updated: Jan 25, 2026

09:41
An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
9.1K
Circulating microRNAs and Their Role in Multiple Myeloma
Cinzia Federico1,2, Antonio Sacco3,4, Angelo Belotti5
1Clinical Research Development and Phase I Unit, ASST Spedali Civili di Brescia, 25123 Brescia, Italy. cinziafederico84@gmail.com.
Non-Coding RNA
|May 5, 2019
Summary
This review summarizes microRNA research in multiple myeloma (MM), highlighting their role in disease progression and potential for prognostic stratification in MM patients.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Multiple myeloma (MM) is a cancer of plasma cells, exhibiting significant genomic and transcriptomic clonal heterogeneity.
- Emerging research emphasizes the crucial role of tumor microenvironment interactions in MM pathogenesis and progression.
- Small non-coding RNAs, particularly microRNAs, are increasingly recognized as key regulators of MM biology.
Purpose of the Study:
- To review recent advancements in microRNA research concerning multiple myeloma.
- To explore the function of microRNAs in MM pathogenesis and progression.
- To discuss the potential of circulating microRNAs for prognostic stratification in MM patients.
Main Methods:
- Literature review of recent studies on microRNAs and circulating microRNAs in multiple myeloma.
- Analysis of findings related to microRNA regulation of MM biology.
- Synthesis of evidence on the prognostic value of circulating microRNAs.
Main Results:
- MicroRNAs are critical regulators of multiple myeloma cell biology.
- Circulating microRNAs show promise as biomarkers for prognostic stratification.
- Tumor-stromal interactions involving microRNAs influence MM pathogenesis.
Conclusions:
- MicroRNAs play a significant role in the development and progression of multiple myeloma.
- Circulating microRNAs offer a potential non-invasive tool for predicting patient outcomes in MM.
- Further research into microRNA mechanisms can lead to novel therapeutic strategies for MM.
Related Concept Videos
MicroRNAs
24.1K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.1K
MicroRNAs
3.9K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.9K
Fetal Circulation
2.7K
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
2.7K
Coronary Circulation
6.9K
The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
6.9K
Regulation of Expression Occurs at Multiple Steps
25.8K
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
25.8K
Overview of Pulmonary Circulation
2.9K
The pulmonary circulation is a vital system in our body that acts as a bridge between the respiratory and cardiovascular systems. It serves as a transport network for deoxygenated blood from the heart to the lungs and then returns oxygen-rich blood back to the heart.
The process begins with the right ventricle of the heart pumping deoxygenated blood into the pulmonary trunk. This large vessel extends about 5 centimeters before splitting into the left and right pulmonary arteries. These arteries...
The process begins with the right ventricle of the heart pumping deoxygenated blood into the pulmonary trunk. This large vessel extends about 5 centimeters before splitting into the left and right pulmonary arteries. These arteries...
2.9K

