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Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
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    This study presents a novel method to extend the working distance of fiber-based common-path spectral domain optical coherence tomography (SD-OCT) systems. This advancement enhances the capabilities of polarization-insensitive OCT probes for biomedical imaging.

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    Area of Science:

    • Biomedical Optics
    • Optical Coherence Tomography
    • Interferometry

    Background:

    • Fiber-based common-path spectral domain optical coherence tomography (SD-OCT) offers compact and polarization-insensitive imaging, ideal for endoscopic applications.
    • Existing systems often have limited working distances, restricting their utility in certain biomedical imaging scenarios.

    Purpose of the Study:

    • To investigate and demonstrate a method for extending the working distance of a common-path SD-OCT system.
    • To enable noncollinear interference in a free-space interferometer for enhanced imaging range.

    Main Methods:

    • A free-space optical interferometer was employed, splitting the common-path OCT light into two parallel beams using a wavefront-splitting mirror.
    • Noncollinear interference was achieved between the spatially separated sample and reference beams.
    • The distance between the probing fiber end (reference plane) and the sample was maintained at approximately 140 mm.

    Main Results:

    • The proposed method successfully extended the working distance of the common-path SD-OCT system.
    • The system's performance was validated through successful imaging of biological samples.
    • The technique demonstrated the potential for developing advanced polarization-insensitive OCT probes.

    Conclusions:

    • The developed method effectively increases the working distance of common-path SD-OCT systems.
    • This technique is suitable for creating polarization-insensitive OCT probes for diverse biomedical imaging applications.
    • The extended working distance broadens the applicability of SD-OCT in endoscopic and other challenging imaging environments.