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Microwave Photonics Systems Based on Whispering-gallery-mode Resonators
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Side-polished few-mode fiber based surface plasmon resonance biosensor.

Jiangli Dong, Yaxin Zhang, Yajun Wang

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    |May 5, 2019
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    We developed a high-performance few-mode fiber (FMF) surface plasmon resonance (SPR) biosensor. This novel FMF-SPR sensor achieves excellent sensitivity for refractive index and bovine serum albumin (BSA) concentration detection.

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    Area of Science:

    • Optoelectronics
    • Nanotechnology
    • Biomedical Engineering

    Background:

    • High-performance fiber-based sensors rely on precise fiber geometry, parameters, and mode-guiding properties.
    • Surface Plasmon Resonance (SPR) biosensors offer label-free detection but can be limited by factors like spectral line-width and sensitivity.

    Purpose of the Study:

    • To propose and demonstrate a few-mode fiber (FMF)-based SPR biosensor for enhanced sensing performance.
    • To optimize FMF-SPR sensor design through finite element method (FEM) analysis for improved sensitivity and figure of merit (FOM).

    Main Methods:

    • Fabrication of FMF-SPR sensors by side-polishing FMF and coating with a gold film.
    • Optimization of fiber geometry, gold film thickness, and mode selection using FEM.
    • Investigation of refractive index (RI) sensing performance and bovine serum albumin (BSA) detection.

    Main Results:

    • Achieved a highest sensitivity of 4903 nm/RIU and FOM of 46.1 RIU⁻¹ in the RI range of 1.333 to 1.404.
    • Realized an averaged BSA RI sensitivity of 6328 nm/RIU and BSA concentration sensitivity of 1.17 nm/(mg/ml).
    • Obtained a narrower SPR spectrum line-width due to the limited modes in FMF, leading to a higher FOM.

    Conclusions:

    • The FMF-SPR biosensor demonstrates superior sensitivity and FOM compared to conventional designs.
    • The sensor's performance is attributed to optimized fiber geometry, gold film, and mode selection.
    • FMF-SPR sensors, leveraging mode-multiplexing, show significant potential for high-performance, high-throughput biochemical analysis.