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Intrauterine Telemetry to Measure Mouse Contractile Pressure In Vivo
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Intrauterine Microbiota: Missing, or the Missing Link?

Helen J Chen1, Tamar L Gur2

  • 1Department of Neuroscience, Wexner Medical Center at The Ohio State University, Columbus, OH, USA.

Trends in Neurosciences
|May 5, 2019
PubMed
Summary
This summary is machine-generated.

Maternal stress during pregnancy may impact fetal neurodevelopment by altering the intrauterine environment. This review explores how stress-induced microbiome changes could lead to inflammation and neurodevelopmental deficits.

Keywords:
inflammationintrauterine environmentmicrobiomeneurodevelopmentplacentaprenatal stressuterus

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Area of Science:

  • Reproductive biology
  • Neuroscience
  • Microbiology

Background:

  • The intrauterine environment is crucial for fetal development and is implicated in fetal programming.
  • Prenatal stress is linked to neurodevelopmental disorders, with the intrauterine environment potentially mediating this effect.
  • The presence and role of microbes within the uterus are increasingly recognized.

Purpose of the Study:

  • To review evidence for microbial communities in utero.
  • To outline mechanisms of microbial translocation and immune responses in the intrauterine environment.
  • To overview the impact of intrauterine inflammation on neurodevelopment.

Main Methods:

  • Review of preclinical and clinical evidence.
  • Discussion of proposed mechanisms for microbial translocation.
  • Synthesis of findings on intrauterine inflammation and neurodevelopment.

Main Results:

  • Emerging evidence suggests microbial communities exist in the intrauterine environment.
  • Mechanisms for bacterial translocation and subsequent immune responses are proposed.
  • Intrauterine inflammation is linked to neurodevelopmental deficits.

Conclusions:

  • Maternal gestational stress may disrupt maternal microbiomes (oral, gut, vaginal).
  • This disruption could facilitate bacterial translocation to the intrauterine space.
  • Resulting intrauterine inflammation may lead to fetal neurodevelopmental deficits.