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Mechanisms, Predictors, and Challenges in Assessing and Managing Painful Chemotherapy-Induced Peripheral Neuropathy
Grace A Kanzawa-Lee1, Robert Knoerl2, Clare Donohoe1
1School of Nursing, University of Michigan, Ann Arbor, MI.
Seminars in Oncology Nursing
|May 5, 2019
Summary
Predicting and managing chronic painful chemotherapy-induced peripheral neuropathy (CIPN) requires more research. Early identification and palliative care are key to improving cancer survivors' quality of life.
Area of Science:
- Oncology
- Neurology
- Palliative Care
Background:
- Chemotherapy-induced peripheral neuropathy (CIPN) is a common and potentially debilitating side effect of cancer treatment.
- Chronic painful CIPN significantly impacts cancer survivors' physical function and quality of life.
Purpose of the Study:
- To review known predictors and pathophysiological mechanisms of chronic painful CIPN.
- To identify challenges in assessing and managing this condition in cancer survivors.
Main Methods:
- Literature search conducted across PubMed/Medline, CINAHL, Scopus, and PsycINFO databases.
- Synthesis of existing research on CIPN predictors, mechanisms, and management.
Main Results:
- Current research on chronic painful CIPN is limited.
- Predictors and detailed pathophysiological mechanisms require further elucidation.
- Assessment and management strategies face significant challenges.
Conclusions:
- Additional research is crucial for developing effective assessment tools and management options for chronic painful CIPN.
- Proactive identification of CIPN predictors and early palliative management are essential.
- Addressing CIPN can mitigate its adverse effects on cancer survivors' well-being.
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