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Updated: Jan 25, 2026
29:13
Microbial Communities in Nature and Laboratory - Interview
Published on: May 28, 2007
6.8K
Microbial evolutionary medicine: from theory to clinical practice.
Sandra B Andersen1, B Jesse Shapiro2, Christina Vandenbroucke-Grauls3
1Langone Medical Center, New York University, New York, NY, USA; The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
The Lancet. Infectious Diseases
|May 5, 2019
Summary
Traditional disease control is insufficient. Evolutionary medicine offers a framework to understand and manage microbial communities, addressing challenges like antibiotic resistance and chronic diseases for better human health outcomes.
Area of Science:
- Integrative biology
- Microbial ecology
- Evolutionary medicine
Background:
- Traditional medicine struggles with evolving disease landscapes, including chronic illnesses and antibiotic-resistant infections.
- Altered immunity and inflammation are key drivers of non-communicable chronic diseases.
- The rise of antimicrobial resistance poses a significant threat to public health.
Purpose of the Study:
- To explore the evolutionary medicine framework for understanding the microbiome's influence on human health.
- To highlight the potential of evolutionary medicine in addressing critical health challenges.
- To integrate diverse scientific disciplines for a holistic approach to microbial health.
Main Methods:
- Reviewing current literature on evolutionary medicine and the microbiome.
- Integrating concepts from ecology, evolutionary biology, microbiology, and bioinformatics.
- Applying a multidisciplinary approach to clinical expertise.
Main Results:
- The evolutionary medicine framework provides a novel approach to predict and manipulate microbial impacts on health.
- This framework is crucial for detecting microbial transmission and predicting antimicrobial resistance.
- Understanding complex microbe-microbe and human-microbe interactions is central to this approach.
Conclusions:
- Evolutionary medicine offers a powerful paradigm shift for tackling modern health challenges.
- Integrating diverse scientific fields is essential for managing the microbiome's role in health and disease.
- This approach holds promise for developing innovative strategies against infectious diseases and chronic conditions.
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