Related Experiment Video
Updated: Jan 25, 2026
09:10
Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents
Published on: November 1, 2019
11.5K
Longitudinal changes in Mediterranean diet and transition between different obesity phenotypes.
J Konieczna1, A Yañez2, M Moñino1
1Instituto de Investigación Sanitaria Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
Clinical Nutrition (Edinburgh, Scotland)
|May 5, 2019
Summary
Improving adherence to the Mediterranean diet (MedDiet) is linked to healthier obesity phenotypes. Increased MedDiet adherence promotes metabolic health and can prevent obesity development in certain groups.
Area of Science:
- Nutrition Science
- Metabolic Health
- Obesity Research
Background:
- Specific dietary patterns' impact on obesity phenotypes remains unclear.
- Investigating longitudinal changes in Mediterranean diet (MedDiet) adherence is crucial for understanding obesity phenotype transitions.
Purpose of the Study:
- To determine the association between longitudinal changes in MedDiet adherence and shifts between obesity phenotypes.
- To analyze how adherence to the traditional MedDiet influences metabolic and body size-related health categories.
Main Methods:
- Utilized data from 5801 high cardiovascular risk participants in the PREDIMED trial.
- Measured MedDiet adherence using the 14-point Mediterranean Diet Adherence Screener (MEDAS).
- Employed Cox regression models with repeated measures and Markov chain assumptions to analyze transitions between four obesity phenotypes (MHO, MAO, MHNO, MANO) over 5 years.
Main Results:
- A 2-point increase in MEDAS score was associated with a 16% greater likelihood of abnormal obese individuals becoming metabolically healthy obese (MAO to MHO).
- Increased MEDAS adherence reduced the risk of metabolically healthy obese individuals becoming abnormal obese (MHO to MAO) by 14%.
- Higher MEDAS adherence decreased the risk of metabolically healthy non-obese individuals becoming metabolically unhealthy obese (MHNO to MHO) by 18% and increased the likelihood of abnormal non-obese women transitioning to metabolically healthy non-obese (MANO to MHNO) by 20%.
Conclusions:
- Greater adherence to the traditional Mediterranean diet is associated with transitions towards healthier obesity phenotypes.
- MedDiet adherence promotes metabolic health improvements in individuals with abnormal obesity and metabolically healthy obesity.
- MedDiet adherence protects against obesity incidence in metabolically healthy non-obese individuals and benefits abnormal non-obese women.
Related Concept Videos
02:20Longitudinal Research
13.2K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.2K
02:31Phase Transitions
22.8K
Whether solid, liquid, or gas, a substance's state depends on the order and arrangement of its particles (atoms, molecules, or ions). Particles in the solid pack closely together, generally in a pattern. The particles vibrate about their fixed positions but do not move or squeeze past their neighbors. In liquids, although the particles are closely spaced, they are randomly arranged. The position of the particles are not fixed—that is, they are free to move past their neighbors to...
22.8K
01:24Obesity
1.2K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.2K
02:58Properties of Transition Metals
29.7K
Transition metals are defined as those elements that have partially filled d orbitals. As shown in Figure 1, the d-block elements in groups 3–12 are transition elements. The f-block elements, also called inner transition metals (the lanthanides and actinides), also meet this criterion because the d orbital is partially occupied before the f orbitals.
29.7K
01:58Cooperative Allosteric Transitions
8.7K
Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
8.7K
02:39Phase Transitions: Vaporization and Condensation
20.8K
The physical form of a substance changes on changing its temperature. For example, raising the temperature of a liquid causes the liquid to vaporize (convert into vapor). The process is called vaporization—a surface phenomenon. Vaporization occurs when the thermal motion of the molecules overcome the intermolecular forces, and the molecules (at the surface) escape into the gaseous state. When a liquid vaporizes in a closed container, gas molecules cannot escape. As these gas phase molecules...
20.8K