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Updated: Oct 3, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Association between acute ischemic stroke etiology and macroscopic aspect of retrieved clots: is a clot's color a
Alessandro Sgreccia1, Zoé Duchmann2, Jean Philippe Desilles3
1Neuroradiology - Interventional Radiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Background:
Few case reports have considered the chromatic aspect of retrieved clots and the possible association with their underlying etiology.
Objective:
The aim of our study was to analyze the frequency of the TOAST ischemic stroke typical (atrial fibrillation, dissection, atheroma) and atypical (infective endocarditis, cancer-related, valve-related thrombi) etiologies depending on the chromatic aspect of retrieved clots.
Methods:
A total of 255 anonymized and standardized clot photos of consecutive patients treated by mechanical thrombectomy for acute ischemic stroke were included. A double-blind evaluation was performed by two senior interventional neuroradiologists, who classified the visual aspects of the clots into two main patterns: red/black or white. Main patient characteristics, distribution of underlying stroke etiologies, and outcomes were compared between the two study groups.
Results:
The inter-reader agreement for clot colors was excellent (k=0.78). Two hundred and thirty-three patients were classified as having red/black clots and 22 as having white clots. A statistically significant association (p=0.001) between atypical etiologies and white clots was observed.
Conclusions:
White clots were significantly associated with atypical etiologies in this cohort,in particular, with infectious endocarditis.
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