Related Experiment Video

Updated: Jan 25, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

12.5K

Serum beta2-microglobulin levels are highly associated with the risk of acute ischemic stroke

Sen Qun1,2, Fuyong Hu3, Guoping Wang4

  • 1Department of Neurology, The First Affiliated Hospital of the University of Science and Technology of China (Anhui Provincial Hospital), Hefei City, Anhui, China. qunsen6163@163.com.

Scientific Reports
|May 5, 2019
PubMed

Insights

Serum beta2-microglobulin (β2M) is elevated in acute ischemic stroke (AIS) patients, increasing stroke risk. Higher β2M levels correlate with stroke severity and subtypes, indicating its role in AIS.

Area of Science:

  • Neuroscience
  • Immunology
  • Biochemistry

Background:

  • Inflammation plays a key role in cell death and survival following ischemic stroke.
  • Beta2-microglobulin (β2M) is a significant inflammation marker, but its specific role in acute ischemic stroke (AIS) remains unclear.

Purpose of the Study:

  • To investigate the association between serum β2M levels and the risk of AIS.
  • To explore the relationship between serum β2M and stroke severity (NIHSS), etiological subtypes (TOAST), and risk scores (ESRS) in AIS patients.

Main Methods:

  • Retrospective analysis of clinical and biochemical data from 202 AIS patients, 41 intracerebral hemorrhage (ICH) patients, and 253 healthy controls.
  • Utilized three binary logistic regression models to assess the correlation between β2M and AIS risk.
  • Examined the relationship between serum β2M and NIHSS, TOAST subtypes, and ESRS in AIS patients.

Main Results:

  • Serum β2M levels were significantly higher in AIS patients compared to ICH patients and healthy controls.
  • Elevated β2M levels were associated with increased odds of AIS.
  • Serum β2M showed a significant positive correlation with the Essen Stroke Risk Score (ESRS) and varied across different TOAST classifications of AIS.

Conclusions:

  • Serum β2M is a potential biomarker associated with the risk and severity of acute ischemic stroke.
  • Further research into β2M's role in stroke pathogenesis may offer new therapeutic targets.

More Related Videos

Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research07:34

Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research

Published on: December 15, 2023

3.3K
An In Vivo Assessment of Blood-Brain Barrier Disruption in a Rat Model of Ischemic Stroke12:19

An In Vivo Assessment of Blood-Brain Barrier Disruption in a Rat Model of Ischemic Stroke

Published on: March 11, 2018

12.1K

Related Concept Videos

Relative Risk01:12

Relative Risk

Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.0K
High-Level and Low-Level Awareness01:19

High-Level and Low-Level Awareness

Controlled processes in human consciousness represent high-alert mental states where individuals deliberately focus their attention on achieving specific goals. Controlled processes can be seen in situations like mastering new technology, where a person might become so absorbed that they ignore surrounding distractions. Such processes involve selective attention, requiring one to concentrate on particular elements of experience while disregarding others. These are governed by executive...
638
Leveling Effect01:29

Leveling Effect

In acid-base chemistry, the leveling effect refers to the limitation imposed by the solvent on the strength of acids and bases in solution. When a base stronger than the solvent's conjugate base is used, it deprotonates the solvent until the base is entirely consumed, making it ineffective against weaker acids. Conversely, an acid stronger than the solvent's conjugate acid protonates the solvent until the acid is depleted, rendering it ineffective against weaker bases. Essentially, the...
1.4K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.3K
Levels of Organization01:09

Levels of Organization

Biological organization is the classification of biological structures, ranging from atoms at the bottom of the hierarchy to the Earth's biosphere. Each level of the hierarchy represents an increase in complexity that builds upon the previous level.
Molecules Are Composed of Atoms, and Biomolecules Are Assembled from Molecules:
The most basic levels include atoms, molecules, and biomolecules. Atoms, the smallest unit of ordinary matter, are composed of a nucleus and electrons. Molecules...
139.4K
Fermi Level01:18

Fermi Level

The Fermi-Dirac function is represented by an S-shaped curve indicating the probability of an energy state being occupied by an electron at a given temperature. The Fermi level is the energy level at which there is a fifty percent chance of finding an electron, and it is positioned between the lower-energy valence band and the higher-energy conduction band.
At absolute zero temperature, electrons fill all energy states up to the Fermi level, leaving upper states empty. As the temperature rises,...
1.7K