Efficient ¹⁶⁹ Yb high-dose-rate brachytherapy source production using reactivation

To present and quantify the effectiveness of a method for the efficient production of ¹⁶⁹ Yb high-dose-rate brachytherapy sources with 27 Ci activity upon clinical delivery, which have about the same dose rate in water at 1 cm from the source center as 10 Ci ¹⁹² Ir sources.

A theoretical framework for ¹⁶⁹ Yb source activation and reactivation using thermal neutrons in a research reactor and ¹⁶⁸ Yb-Yb₂ O₃ precursor is derived and benchmarked against published data. The model is dependent primarily on precursor ¹⁶⁸ Yb enrichment percentage, active source volume of the active element, and average thermal neutron flux within the active source.

Efficiency gains in ¹⁶⁹ Yb source production are achievable through reactivation, and the gains increase with active source volume. For an average thermal neutron flux within the active source of 1 × 10¹⁴  n cm^-2  s^-1 , increasing the active source volume from 1 to 3 mm³ decreased reactor-days needed to generate one clinic-year of ¹⁶⁹ Yb from 256 days yr^-1 to 59 days yr^-1 , and 82%-enriched precursor dropped from 80 mg yr^-1 to 21 mg yr^-1 . A resource reduction of 74%-77% is predicted for an active source volume increase from 1 to 3 mm³ .

Dramatic cost savings are achievable in ¹⁶⁹ Yb source production costs through reactivation if active sources larger than 1 mm³ are used.