[Effect of lysine on cephalosporin biosynthesis and morphogenesis in Acremonium chrysogenum]

The effect of exogenic lysine on production of cephalosporin by auxotrophic and prototrophic strains of A. chrysogenum and their development was studied. It was shown that lysine added to the medium at a concentration of 0.5 or 1 mg/ml partially eliminated the effect of catabolic repression by glucose and had a stimulating effect on production of cephalosporin in the presence of sucrose. Both phenomena were most pronounced in the prototrophic strain 309-A. High concentrations of lysine (10 mg/ml) inhibited cephalosporin biosynthesis more intensively in the auxotrophic strain 291-A than in the prototrophic strain 309-A. Marked differences in the character of the culture development in media supplemented with 1 or 10 mg/ml of lysine were also observed.