Liquid biopsy: Circulating exosomal long noncoding RNAs in cancer

Area of Science:

• Oncology
• Biomarker Discovery
• Molecular Diagnostics

Background:

• Cancer remains a major global health challenge despite treatment advances.
• Liquid biopsy enables early cancer detection and real-time tumor monitoring.
• Current liquid biopsy focuses on circulating tumor cells (CTCs) and DNA (ctDNA).

Purpose of the Study:

• To review the clinical potential of circulating exosomal long noncoding RNAs (lncRNAs) as liquid biopsy biomarkers.
• To explore their role in cancer diagnosis, prognosis, and treatment response.
• To provide insights into precision medicine for oncology.

Main Methods:

• Literature review focusing on exosomal lncRNAs in cancer.
• Analysis of studies investigating lncRNAs in exosomes for cancer detection.
• Evaluation of lncRNAs' association with tumorigenesis, metastasis, and therapy response.

Main Results:

• Circulating exosomal lncRNAs are closely linked to cancer development and progression.
• These lncRNAs show significant potential as sensitive and specific biomarkers.
• Evidence supports their utility across various stages of cancer management.

Conclusions:

• Circulating exosomal lncRNAs represent a valuable source for liquid biopsy in oncology.
• They offer novel avenues for precise cancer diagnosis and personalized treatment strategies.
• Further research can solidify their role in clinical practice for improved patient outcomes.