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Development of the summary of findings table for network meta-analysis
Juan José Yepes-Nuñez1, Shelly-Anne Li2, Gordon Guyatt3
1Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada; School of Medicine, Universidad de los Andes, Carrera 7 No. 116 - 05, Bogotá, D.C., Colombia.
Objectives:
The aim of the study was to develop a Grading of Recommendations, Assessment, Development and Evaluation (GRADE) summary of findings (SoF) table format that displays the critical information from a network meta-analysis (NMA).
Study Design And Setting:
We applied a user experience model for data analysis based on four rounds of semistructured interviews.
Results:
We interviewed 32 stakeholders who conduct or use MA. Four rounds of interviews produced six candidate NMA-SoF tables. Users found a final NMA-SoF table that included the following components highly acceptable: (1) details of the clinical question (PICO), (2) a plot depicting network geometry, (3) relative and absolute effect estimates, (4) certainty of evidence, (5) ranking of treatments, and (6) interpretation of findings.
Conclusion:
Using stakeholder feedback, we developed a new GRADE NMA-SoF table that includes the relevant components that facilitate understanding NMA findings and health decision-making.
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