Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

9.8K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.8K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.6K
3.6K
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

18.5K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
18.5K
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

7.6K
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.6K
Overview of Cell Death01:30

Overview of Cell Death

9.6K
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
9.6K
Autophagic Cell Death01:18

Autophagic Cell Death

4.4K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
4.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring the Role of Long Non-Coding RNAs in Mediating Cisplatin Resistance in Glioma/Glioblastoma Cells.

International journal of molecular sciences·2026
Same author

Comparative effects of diazepam administration and chronic sleep deprivation on cognitive function and biochemical markers in rats.

Scientific reports·2026
Same author

Retraction notice to "Vanillic acid attenuates effects of transient bilateral common carotid occlusion and reperfusion in rats" [Biomedicine & Pharmacotherapy 96(2017) 667-678].

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Retraction notice to "Corrigendum to "vanillic acid attenuates effects of transient bilateral common carotid occlusion and reperfusion in rats" [Biomed. Pharmacother. 96 (2017) 667-674]" [Biomedicine & Pharmacotherapy 165 (2023) 115061].

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Empagliflozin enhances cisplatin activity in chemo-resistant EJ138 bladder cancer cells: The importance of anti-diabetic medications in cancer treatment.

Scientific reports·2026
Same author

Current Progress and Future Opportunities in Liquid Biopsy for Cancer Detection.

Anti-cancer agents in medicinal chemistry·2026

Related Experiment Video

Updated: Jan 25, 2026

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke
11:32

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke

Published on: January 3, 2025

1.6K

Long non-coding RNAs and cell death following ischemic stroke.

Masoumeh Alishahi1, Farhoodeh Ghaedrahmati2, Tannaz Akbari Kolagar1

  • 1Department of Biology, Tehran North Branch, Islamic Azad University, Tehran, Iran.

Metabolic Brain Disease
|May 6, 2019
PubMed
Summary

Long noncoding RNAs (lncRNAs) are key players in ischemic stroke pathophysiology and neuronal cell death. Understanding lncRNA functions offers promising therapeutic targets for stroke treatment.

Keywords:
Cell deathIschemic strokeLong non-coding RNA

More Related Videos

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

1.1K
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

12.5K

Related Experiment Videos

Last Updated: Jan 25, 2026

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke
11:32

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke

Published on: January 3, 2025

1.6K
Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

1.1K
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

12.5K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Stroke is a leading cause of death and disability globally.
  • Reducing neuronal cell death after ischemic stroke is a critical therapeutic goal.
  • Understanding the molecular mechanisms of ischemic stroke is essential for developing effective treatments.

Purpose of the Study:

  • To review the current understanding of long noncoding RNAs (lncRNAs) in ischemic stroke.
  • To highlight the role of specific lncRNAs in neuronal cell death during cerebral ischemia.
  • To identify potential therapeutic targets for ischemic stroke based on lncRNA functions.

Main Methods:

  • Literature review of studies on lncRNAs in ischemic stroke.
  • Analysis of aberrant lncRNA expression in animal models of ischemic stroke.
  • Focus on lncRNAs involved in neuronal cell death pathways.

Main Results:

  • lncRNAs are significantly dysregulated in ischemic stroke.
  • Specific lncRNAs play crucial roles in the pathophysiology of cerebral ischemia.
  • lncRNAs and their targets influence genetic regulation at the molecular level.

Conclusions:

  • lncRNAs represent a promising avenue for therapeutic intervention in ischemic stroke.
  • Further research into lncRNA mechanisms may lead to novel treatment strategies.
  • Targeting specific lncRNAs could mitigate neuronal cell death and improve stroke outcomes.