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Acute decrease in plasma testosterone and appetite after either glucose or protein beverages in adolescent males.

Alexander Schwartz1,2, Sascha Hunschede1, Russel John Scott Lacombe1

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Clinical Endocrinology
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Summary
This summary is machine-generated.

Protein and glucose consumption acutely decrease testosterone and luteinizing hormone (LH) in adolescent males. This study found no evidence that these hormonal changes affect appetite or food intake.

Keywords:
appetitefood intakeglucosehormonesproteintestosterone

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Area of Science:

  • Endocrinology
  • Nutritional Science
  • Adolescent Health

Background:

  • Chronic testosterone levels are linked to food intake.
  • Limited research exists on the acute effects of testosterone on appetite.
  • The impact of protein and glucose on testosterone response needs further investigation.

Purpose of the Study:

  • To examine the acute effects of protein and glucose consumption on testosterone levels in adolescent males.
  • To investigate the influence of food intake on testosterone and luteinizing hormone (LH).
  • To determine if acute hormonal changes affect appetite and subsequent food intake.

Main Methods:

  • A randomized crossover study involving 23 adolescent males (12-18 years).
  • Participants consumed beverages with whey protein (1g/kg), glucose (1g/kg), or a calorie-free control.
  • Plasma testosterone, LH, GLP-1, ghrelin, glucose, insulin, and subjective appetite were measured. Food intake was assessed post-consumption.

Main Results:

  • Both protein and glucose acutely decreased plasma testosterone and LH levels.
  • Testosterone decrease persisted longer after protein compared to glucose.
  • Testosterone positively correlated with LH and negatively with GLP-1; no association with appetite or food intake was observed.

Conclusions:

  • Protein and glucose ingestion lead to acute reductions in testosterone and LH in adolescent males.
  • The physiological relevance of these acute hormonal changes requires further study.
  • This research did not find support for testosterone's role in the acute regulation of food intake.