Related Experiment Video
Updated: Jan 25, 2026

Viral Transgene Expression in Rodent Hearts and the Assessment of Cardiac Arrhythmia Risk
Published on: July 27, 2022
An Efficient Cardiac Arrhythmia Onset Detection Technique Using a Novel Feature Rank Score Algorithm
Hemalatha Karnan1, N Sivakumaran2, Rajajeyakumar Manivel3
1National Institute of Technology, Tiruchirappalli, India. hema.ae2012@gmail.com.
Insights
This study estimates cardiac output (CO) from blood flow to identify left-ventricular arrhythmias (LVA) using ECG. A novel algorithm effectively selects features for accurate LVA detection.
Area of Science:
- Cardiovascular physiology
- Biomedical signal processing
- Medical diagnostics
Background:
- Cardiovascular blood flow abnormalities, particularly left-ventricular arrhythmias (LVA), are significant health concerns.
- Electrocardiogram (ECG) interpretation is crucial for identifying these anomalies.
- Blood rheology and flow dynamics are intrinsically linked to cardiac arrhythmias.
Purpose of the Study:
- To estimate cardiac output (CO) using blood flow rate analysis for identifying subjects with LVA.
- To develop and validate a novel algorithm for optimal feature selection in LVA detection.
- To utilize ECG signals for accurate classification of LVA.
Main Methods:
- Cardiac output (CO) estimation derived from stroke volume (SV), end-diastolic/systolic volumes (EDV/ESV), and heart rate derived from ECG R-R intervals.
- Development of the Feature Ranking Score (FRS) algorithm to score and select optimal features from ECG signals.
- Classification of LVA using the Least Square-Support Vector Machine (LS-SVM) classifier with selected features.
- Validation using signals from the public domain MIT-BIH arrhythmia database.
Main Results:
- The study successfully estimated CO as a vital parameter for LVA identification.
- The FRS algorithm effectively identified and selected optimal features for classification.
- The LS-SVM classifier demonstrated proficiency in identifying LVA using the selected features.
- The proposed technique showed validation in identifying LVA from ECG signals and blood flow characteristics.
Conclusions:
- Deviation in CO values from nominal ranges indicates a higher susceptibility to LVA.
- The FRS algorithm combined with LS-SVM provides an effective method for LVA detection.
- This approach offers a promising tool for early identification and management of LVA using ECG and blood flow analysis.
Abstract:
The interpretation of various cardiovascular blood flow abnormalities can be identified using Electrocardiogram (ECG). The predominant anomaly due to the blood flow dynamics leads to the occurrence of cardiac arrhythmias in the cardiac system. In this work, estimation of cardiac output (CO) parameter using blood flow rate analysis is carried out, which is a vital parameter to identify the subjects with left- ventricular arrhythmias (LVA). In particular, LVA is a resultant component of characteristic changes in blood rheology (blood flow rate). The CO is an intrinsic parameter derived from the stroke volume (SV) characterized by end-diastolic/systolic volumes (EDV/ESV) and heart rate. The pumping of blood from left ventricle (LV) reconciles in to R-R intervals depicted on ECG, which are used for heart rate estimation. The deviation from the nominal values of CO implies that, the subject is more prone to LVA. Further, the identification of subjects with LVA is accomplished by computing the features from the ECG signals. The proposed Feature Ranking Score (FRS) algorithm employs different statistical parameters to label the score of the extracted features. The feature score enables the selection optimal features for classification. The optimal features are further given to the Least Square- Support Vector Machine (LS-SVM) classifier for training and testing phases. The signals are acquired from public domain MIT-BIH arrhythmia database, used for validating the proposed technique for identifying the LVA using blood flow.
Related Concept Videos
Mechanism of Cardiac Arrhythmias
Ranks
ECG Interpretation of Arrhythmias I: Sinus Arrhythmias
Types of Arrhythmias
Sinus Node Arrhythmias
Sinus Bradycardia: Originating from the sinoatrial (SA) node, sinus bradycardia involves slower impulses, resulting in a heart rate of less than 60 beats per minute (bpm). Causes include sleep, vagal stimulation, beta-blockers, hypothyroidism,...
Spearman's Rank Correlation Test
Spearman's test calculates correlation by...
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias
Wilcoxon Rank-Sum Test

