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Updated: Jan 25, 2026

Electrochemotherapy of Tumours
Published on: December 15, 2008
SIRT1: a potential tumour biomarker and therapeutic target
Bin Zhao1,2,3, Xin Li1,2,3, Liangfu Zhou1,2,3
1Research & Development Institute of Northwestern Polytechnical University in Shenzhen , Shenzhen , China.
Abstract:
SIRT1, which is highly homologous to yeast silent information regulator 2, has recently garnered tremendous attention because of its various regulatory effects in several pathological conditions. Numerous studies have found that SIRT1 is highly expressed in a broad range of tumours compared with the paracancerous tissue. However, the role of SIRT1 in malignancies has yet to be systematically elucidated, and its use as a promising biomarker or therapeutic target for tumours has not been well-reported. Herein, we focus on the roles of SIRT1 in cancers and summarise the potential use of SIRT1 as a promising tumour biomarker or therapeutic target.
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