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High-resolution Volume Imaging of Neurons by the Use of Fluorescence eXclusion Method and Dedicated Microfluidic Devices

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Volume-of-interest Imaging Using Multiple Aperture Devices.

W Wang¹, G J Gang¹, J H Siewerdsen¹

¹Department of Biomedical Engineering, Johns Hopkins University, Baltimore MD, USA 21205.

Proceedings of Spie--The International Society for Optical Engineering

|May 7, 2019

Summary

Volume-of-interest (VOI) imaging using multiple aperture devices (MAD) significantly reduces computed tomography (CT) dose while maintaining image quality. This novel approach addresses hardware limitations and reconstruction challenges for clinical applications.

Keywords:

Fluence field modulation model-based iterative reconstruction volume-of-interest imaging

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Area of Science:

Medical Imaging
Radiological Physics

Background:

Volume-of-interest (VOI) imaging offers potential for dose reduction in computed tomography (CT).
Challenges include hardware limitations and the interior tomography reconstruction problem.

Purpose of the Study:

To propose a general approach for VOI imaging using multiple aperture devices (MAD).
To dynamically tailor X-ray fluence for prescribed VOIs using MAD trajectories.

Main Methods:

Designed MAD trajectories for dynamic fluence tailoring.
Developed a penalized-likelihood reconstruction algorithm for truncated projections with scout views.
Conducted physical experiments for non-centered elliptic VOIs.

Main Results:

Demonstrated feasibility for non-centered elliptic VOIs.
Achieved high image quality comparable to standard protocols.
Significantly decreased total radiation dose.

Conclusions:

MAD-based VOI imaging effectively reduces CT dose while preserving image quality.
This approach shows promise for dose reduction in clinical CT settings.