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Bacteriostatic Potency of Fe2O3 Against Enterococcus faecalis in Synergy with Antibiotics by DDST Method

Erfan Shahbazi1, Firouzeh Morshedzadeh2, Davood Zaeifi3

  • 1Department of Microbiology, Shahid Beheshti University, Tehran, Iran.

Avicenna Journal of Medical Biotechnology
|May 7, 2019
PubMed
Abstract

Insights

Iron oxide nanoparticles show bacteriostatic effects against Enterococcus faecalis. Combining these nanoparticles with antibiotics enhances their antimicrobial potency, offering potential for bacterial inhibition.

Area of Science:

  • Nanotechnology
  • Materials Science
  • Microbiology

Background:

  • Investigated the bacteriostatic potency of Iron oxide (Fe2O3) nanoparticles against Enterococcus faecalis (E. faecalis).
  • Tested against both a clinical E. faecalis sample and the ATCC11700 strain.

Purpose of the Study:

  • To determine the bacteriostatic concentration of Fe2O3 nanoparticles.
  • To evaluate the antimicrobial characteristics and kinetics of Fe2O3 nanoparticles against E. faecalis.
  • To assess the synergistic effects of Fe2O3 nanoparticles with antibiotics.

Main Methods:

  • Determined Minimum Inhibitory Concentration (MIC) of Fe2O3 nanoparticles.
  • Assessed bacterial death kinetics and susceptibility constants at varying concentrations and treatment times (0-360 min).
  • Investigated nanoparticle synergism with Ceftazidime and Clindamycin.

Main Results:

  • Fe2O3 nanoparticles (10-50 nm) exhibited significant susceptibility against E. faecalis strains.
  • Bacterial inhibition increased with treatment time up to a certain concentration, beyond which growth was observed.
  • Synergistic combinations of Fe2O3 nanoparticles with Ceftazidime and Clindamycin showed enhanced antimicrobial activity.

Conclusions:

  • Fe2O3 nanoparticles demonstrate potent antimicrobial effects against E. faecalis at specific concentrations over time.
  • The antimicrobial efficacy of Fe2O3 nanoparticles can be enhanced through combination therapy with antibiotics.
  • Fe2O3 nanoparticles show potential for developing novel strategies for bacterial inhibition.
Keywords:
Enterococcus faecalisFerric oxideNanopaticles

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