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Updated: Jan 25, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Nickel-catalyzed C-N bond activation: activated primary amines as alkylating reagents in reductive cross-coupling
Huifeng Yue1, Chen Zhu1, Li Shen1
1Institute of Organic Chemistry , RWTH Aachen University , Landoltweg 1 , D-52074 Aachen , Germany .
Abstract:
Nickel-catalyzed reductive cross coupling of activated primary amines with aryl halides under mild reaction conditions has been achieved for the first time. Due to the avoidance of stoichiometric organometallic reagents and external bases, the scope regarding both coupling partners is broad. Thus, a wide range of substrates, natural products and drugs with diverse functional groups are tolerated. Moreover, experimental mechanistic investigations and density functional theory (DFT) calculations in combination with wavefunction analysis have been performed to understand the catalytic cycle in more detail.
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