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Updated: Jan 25, 2026

The Use of Mouse Mammary Tumor Cells in an In Vitro Invasion Assay as a Measure of Oncogenic Cell Behavior
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RUNX family: Oncogenes or tumor suppressors (Review)

Beatriz Andrea Otálora-Otálora1, Berta Henríquez2, Liliana López-Kleine3

  • 1Medicine Faculty, National University of Colombia, Bogotá 111321, Colombia.

Oncology Reports
|May 7, 2019
PubMed

Insights

Runt-related transcription factor (RUNX) proteins are key regulators in embryonic development and cancer. This review explores their dual role in promoting and suppressing tumors, highlighting their potential as cancer biomarkers and therapeutic targets.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Runt-related transcription factors (RUNX) are master regulators of embryonic development.
  • The RUNX family is increasingly implicated in regulating cancer-associated signaling pathways.
  • RUNX proteins exhibit both oncogenic and tumor suppressor functions in various cancers.

Purpose of the Study:

  • To review the biological characteristics and regulatory roles of RUNX proteins in cancer.
  • To analyze experimental evidence supporting the dual functions of RUNX proteins in oncogenesis.
  • To underscore the significance of RUNX proteins as potential cancer biomarkers and therapeutic targets.

Main Methods:

  • Literature review of RUNX protein functions in cancer.
  • Analysis of experimental data on RUNX oncogenic and tumor suppressor activities.
  • Synthesis of information on RUNX protein roles in cancer development and progression.

Main Results:

  • RUNX proteins possess a dual role, acting as both oncogenes and tumor suppressors.
  • Evidence demonstrates RUNX proteins' involvement in regulating key cancer signaling pathways.
  • RUNX proteins are identified as important factors in various cancer types.

Conclusions:

  • RUNX proteins play a critical role in cancer, with context-dependent oncogenic and tumor suppressor functions.
  • Understanding RUNX protein dual roles is crucial for developing targeted cancer diagnostics and therapies.
  • Further molecular studies on RUNX proteins are essential for advancing cancer treatment strategies.

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