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Low-Voltage Irreversible Electroporation Using a Comb-Shaped Contact Electrode.

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    A new contact irreversible electroporation (IRE) method uses a miniature electrode to ablate tumor cells. This technique significantly reduces the required voltage, making it a promising less invasive cancer therapy.

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    Area of Science:

    • Biomedical Engineering
    • Oncology
    • Medical Devices

    Background:

    • Irreversible electroporation (IRE) is a minimally invasive tumor ablation therapy using high-voltage electrical pulses.
    • Conventional IRE requires high voltages, limiting its application and potentially causing collateral damage.
    • Developing lower-voltage IRE methods is crucial for broader clinical adoption and improved patient outcomes.

    Purpose of the Study:

    • To design and evaluate a novel comb-shaped miniature electrode for contact irreversible electroporation (contact IRE).
    • To reduce the voltage required for effective tumor cell ablation.
    • To assess the efficacy of contact IRE in a tissue phantom model.

    Main Methods:

    • Fabrication of a miniature comb-shaped electrode using inkjet patterning and etching.
    • Application of short electrical pulses (10-100 μs) to a tissue phantom.
    • Measurement of necrotized tissue area to quantify ablation effectiveness.

    Main Results:

    • The miniature electrode achieved a maximum ablation depth of 400 μm at a low voltage of 20 V.
    • Insulation and adjuvants increased ablation depth by 26% and area by 40%.
    • Successful necrotization of cells in a tissue phantom was demonstrated with minimal voltage.

    Conclusions:

    • The developed miniature electrode enables effective cell ablation using contact IRE at significantly reduced voltages.
    • Contact IRE shows potential for treating surface lesions, such as cutaneous and gastrointestinal tumors.
    • This technology offers a less invasive and potentially safer alternative for tumor ablation therapies.