Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Folding01:22

Protein Folding

127.0K
Overview
127.0K
Protein Folding01:25

Protein Folding

11.3K
Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
11.3K
Molecular Chaperones and Protein Folding03:00

Molecular Chaperones and Protein Folding

19.7K
The native conformation of a protein is formed by interactions between the side chains of its constituent amino acids. When the amino acids cannot form these interactions, the protein cannot fold by itself and needs chaperones. Notably, chaperones do not relay any additional information required for the folding of polypeptides; the native conformation of a protein is determined solely by its amino acid sequence. Chaperones catalyze protein folding without being a part of the folded protein.
The...
19.7K
Molecular Chaperones and Protein Folding03:00

Molecular Chaperones and Protein Folding

14.9K
14.9K
Quantifying Work02:30

Quantifying Work

24.2K
As a system undergoes a change, its internal energy can change, and energy can be transferred from the system to the surroundings, or from the surroundings to the system.
24.2K
Quantifying Heat02:46

Quantifying Heat

61.8K
Thermal Energy Microscopically, thermal energy is the kinetic energy associated with the random motion of atoms and molecules. Temperature is a quantitative measure of “hot” or “cold”, which depends on the amount of thermal energy. When the atoms and molecules in an object are moving or vibrating quickly, they have a higher average kinetic energy (KE) (or higher thermal energy), and the object is perceived as “hot”, or it is described as being at a higher temperature. When the...
61.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preliminary Transcriptomic Effects of Lateralized RLN Denervation in Rat Vocal Fold.

The Laryngoscope·2026
Same author

Effects of Antioxidant Therapy with Twendee X on Vocal Function After Phonomicrosurgery: A Randomized Controlled Trial.

Journal of voice : official journal of the Voice Foundation·2026
Same author

YAP/TAZ inhibition refines TGF-β signaling to prevent laryngeal fibrosis.

bioRxiv : the preprint server for biology·2026
Same author

EGFR-targeted photoimmunotherapy and its association with the immune microenvironment in locoregional recurrent head and neck squamous cell carcinoma.

Frontiers in immunology·2026
Same author

Vocal-Gender Incongruence, wellbeing, and safety: The medical necessity of gender-affirming vocal training.

International journal of transgender health·2026
Same author

The Regenerative Effects of Intracordal Injection of Basic Fibroblast Growth Factor for Vocal Fold Scar After Burn or Radiotherapy: A Preliminary Report.

Journal of voice : official journal of the Voice Foundation·2026

Related Experiment Video

Updated: Jan 25, 2026

Hemi-laryngeal Setup for Studying Vocal Fold Vibration in Three Dimensions
10:13

Hemi-laryngeal Setup for Studying Vocal Fold Vibration in Three Dimensions

Published on: November 25, 2017

11.4K

Quantifying vocal fold wound-healing biomechanical property changes.

Gregory R Dion1,2,3, Teja Guda2, Shigeyuki Mukudai3

  • 1Dental and Craniofacial Trauma Research Department, U.S. Army Institute of Surgical Research, JBSA Fort Sam Houston, San Antonio, Texas.

The Laryngoscope
|May 7, 2019
PubMed
Summary

Automated microindentation mapping quantifies vocal fold biomechanics and histology. This method provides objective outcomes for developing new vocal fold therapeutics.

Keywords:
Voicebiomechanicsinjurymicroindentationvocal foldwound healing

More Related Videos

Construction and Characterization of a Novel Vocal Fold Bioreactor
11:11

Construction and Characterization of a Novel Vocal Fold Bioreactor

Published on: August 1, 2014

9.6K
Preparation of the Rat Vocal Fold for Neuromuscular Analyses
07:17

Preparation of the Rat Vocal Fold for Neuromuscular Analyses

Published on: May 15, 2020

4.0K

Related Experiment Videos

Last Updated: Jan 25, 2026

Hemi-laryngeal Setup for Studying Vocal Fold Vibration in Three Dimensions
10:13

Hemi-laryngeal Setup for Studying Vocal Fold Vibration in Three Dimensions

Published on: November 25, 2017

11.4K
Construction and Characterization of a Novel Vocal Fold Bioreactor
11:11

Construction and Characterization of a Novel Vocal Fold Bioreactor

Published on: August 1, 2014

9.6K
Preparation of the Rat Vocal Fold for Neuromuscular Analyses
07:17

Preparation of the Rat Vocal Fold for Neuromuscular Analyses

Published on: May 15, 2020

4.0K

Area of Science:

  • Biomechanics
  • Histology
  • Vocal Fold Physiology

Background:

  • Developing novel vocal fold (VF) therapeutics is hindered by a lack of standardized outcome measures.
  • Quantitative assessment of VF biomechanical properties is crucial for therapeutic development.

Purpose of the Study:

  • To hypothesize that automated microindentation-based VF biomechanical property mapping, when matched to histology, permits quantitative assessment.
  • To establish a novel technological approach for correlating functional biomechanics with histology in VF tissues.

Main Methods:

  • Ex vivo study using New Zealand white rabbits with induced VF injury.
  • Automated microindentation mapping to measure normal force, structural stiffness, and displacement.
  • Histological analysis of VF tissues matched to biomechanical measurement points.

Main Results:

  • Biomechanical properties (normal force, stiffness, displacement) in the injury zone changed significantly over time, peaking at day 30.
  • Measurements showed distinct patterns in the injury zone compared to uninjured areas.
  • Biomechanical findings correlated with qualitative histological variations.

Conclusions:

  • Quantifiable vocal fold biomechanical properties can be accurately linked to histological findings.
  • This automated microindentation mapping technique offers a novel, simultaneous correlation of functional biomechanics and histology.
  • The approach is well-suited for future preclinical studies in vocal fold therapeutics.