Related Experiment Video
Updated: Jan 25, 2026

Preparing Silica Aerogel Monoliths via a Rapid Supercritical Extraction Method
Published on: February 28, 2014
Hierarchical silica monolithic tablets as novel carriers for drug delivery
Wojciech Pudło1, Przemysław Borys2, Grzegorz Huszcza3
1Department of Chemical Engineering and Process Design, Faculty of Chemistry, Silesian University of Technology, ks. M. Strzody 7, 44-100 Gliwice, Poland.
Abstract:
This paper proposes the use of carriers with hierarchical porous structures as novel monolithic tablets for modified drug release. The influence of pore structure on the tamsulosin release profile is presented. The hierarchical arrangement of porous structure in monolithic tablets and the deposition of tamsulosin inside the silica carrier enable to control the kinetic of release and the amount of tamsulosin released. We developed a mathematical model of tamsulosin release from two carriers with different hierarchy of meso- and macropores. A model of this nature will allow to predict the release of tamsulosin from other carriers with a similar pore structure. We hope this research will improve the design process of novel carriers, and thus, will allow to tailor the porous structure of a carrier to achieve the desired release profile.
Related Concept Videos
Electron Carriers
Over the many stages of cellular respiration, glucose breaks down into carbon dioxide and water. Electron carriers pick up electrons lost by glucose in these reactions, temporarily storing and releasing them into the electron...
Drug Delivery: Overview
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Drug Absorption Mechanism: Carrier-Mediated Membrane Transport
Facilitated diffusion is a passive process that utilizes human Solute Carrier (SLC) transporters. These transporters bind to the drug, undergo structural...
Drug Delivery: Enteral Route
Drug Delivery: Parenteral Route
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
Drug Delivery: Miscellaneous Routes
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...

