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Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
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Deep Brain Stimulation Generator Replacement in End-Stage Parkinson Disease.

Jonathan Dennis Carlson1, Meghan Palmer1, Aiden Hoefer1

  • 1Inland Neurosurgery and Spine Associates, Spokane, Washington, USA.

World Neurosurgery
|May 7, 2019
PubMed
Summary

Deep brain stimulation (DBS) generator replacement is safe for end-stage Parkinson disease (PD) patients. This study found no infections or complications in 11 end-stage PD patients undergoing generator replacement surgery.

Keywords:
Battery lifeDBSEthicsGenerator replacementParkinson's disease

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Area of Science:

  • Neurosurgery
  • Neurology
  • Movement Disorders

Background:

  • Deep brain stimulation (DBS) is a treatment for Parkinson disease (PD).
  • Replacing DBS generators is necessary as batteries deplete.
  • Risks of DBS generator replacement in end-stage PD patients are not well-documented.

Purpose of the Study:

  • To evaluate the safety and infection risk of DBS generator replacement surgery in end-stage Parkinson disease (PD) patients.

Main Methods:

  • Retrospective analysis of 446 DBS procedures over 20 years.
  • Focused on generator replacement in 11 end-stage PD patients.
  • Evaluated perioperative and delayed infections.

Main Results:

  • Overall infection rate for generator replacement was 0.6% (172 cases).
  • Infection rate for primary lead implantation was 2.5% (232 cases).
  • No infections or complications occurred in the 11 end-stage PD patients.

Conclusions:

  • DBS generator replacement is a low-risk procedure.
  • The surgery is safe even for severely disabled, end-stage PD patients.