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Updated: Jan 25, 2026
11:12
Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
Published on: July 16, 2014
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Deep Brain Stimulation Generator Replacement in End-Stage Parkinson Disease
Jonathan Dennis Carlson1, Meghan Palmer1, Aiden Hoefer1
1Inland Neurosurgery and Spine Associates, Spokane, Washington, USA.
World Neurosurgery
|May 7, 2019
Summary
Deep brain stimulation (DBS) generator replacement is safe for end-stage Parkinson disease (PD) patients. This study found no infections or complications in 11 end-stage PD patients undergoing generator replacement surgery.
Area of Science:
- Neurosurgery
- Neurology
- Movement Disorders
Background:
- Deep brain stimulation (DBS) is a treatment for Parkinson disease (PD).
- Replacing DBS generators is necessary as batteries deplete.
- Risks of DBS generator replacement in end-stage PD patients are not well-documented.
Purpose of the Study:
- To evaluate the safety and infection risk of DBS generator replacement surgery in end-stage Parkinson disease (PD) patients.
Main Methods:
- Retrospective analysis of 446 DBS procedures over 20 years.
- Focused on generator replacement in 11 end-stage PD patients.
- Evaluated perioperative and delayed infections.
Main Results:
- Overall infection rate for generator replacement was 0.6% (172 cases).
- Infection rate for primary lead implantation was 2.5% (232 cases).
- No infections or complications occurred in the 11 end-stage PD patients.
Conclusions:
- DBS generator replacement is a low-risk procedure.
- The surgery is safe even for severely disabled, end-stage PD patients.
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