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Updated: Jan 25, 2026

Semi-Quantitative Analysis of Peptidoglycan by Liquid Chromatography Mass Spectrometry and Bioinformatics
Published on: October 13, 2020
Potential of Liquid Extraction Surface Analysis Mass Spectrometry (LESA-MS) for the Characterization of Polymer-Based
Ambre Issart1, Joanna Szpunar2
1Institute of Analytical and Physical Chemistry for the Environment and Materials (IPREM), UMR 5254CNRS-UPPA, Hélioparc, 2, av. Pr. Angot, 64053 Pau, France. ambre.issart@univ-pau.fr.
Abstract:
Liquid extraction surface analysis mass spectrometry (LESA -MS) is a direct analysis method suitable for the analysis of polymers. It is based on a fast and efficient extraction of polymer components, such as non-intentionally added species (NIAS), post-polymerization residues, or additives, and residues resulting from specific uses followed by their MS detection. In comparison with batch methods, it is a "green" method, using negligible volumes of organic solvents, and it is cost-effective, avoiding lengthy sample preparation procedures. It can be used for the detection of known molecules (targeted analysis), identification of unknown species (exploratory analysis requiring MS/MS) and semi-quantative analysis, if standards are available. The to-date applications of LESA-MS in the field of polymer science are reviewed and critically discussed taking into account the hands-on experience from the authors' laboratory. Future possibilities of LESA applications are highlighted.
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