Avelumab in gastric cancer

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Giandomenico Roviello1, Alberto D'Angelo2, Daniele Generali3

  • 1Department of Health Sciences, University of Florence, Viale Pieraccini, 6, 50139 Florence, Italy.

Immunotherapy
|May 8, 2019
PubMed

Insights

Avelumab, an anti-PD-L1 antibody, shows potential for treating gastric cancer (GC). This review covers its properties, efficacy in clinical trials, and ongoing research for GC treatment.

Area of Science:

  • Oncology
  • Immunotherapy
  • Gastroenterology

Background:

  • Gastric cancer (GC) is a leading cause of cancer death globally, with poor prognosis in metastatic stages.
  • Current treatments like surgery and chemotherapy have limitations for advanced GC.
  • Avelumab, an anti-PD-L1 antibody, is approved for other cancers and is being investigated for GC.

Purpose of the Study:

  • To review the chemical structure and pharmacologic properties of avelumab.
  • To summarize the current efficacy data of avelumab in gastric cancer treatment from clinical trials.
  • To describe ongoing studies evaluating avelumab in GC, alone or in combination therapies.

Main Methods:

  • Literature review of published data on avelumab.
  • Analysis of clinical trial results (Phase I, II, and ongoing) for gastric cancer treatment.
  • Examination of avelumab's mechanism of action and pharmacological profile.

Main Results:

  • Avelumab's structure and properties relevant to cancer therapy are detailed.
  • Clinical trial data on avelumab's efficacy in gastric cancer is presented.
  • Ongoing trials exploring avelumab's use in various GC settings are highlighted.

Conclusions:

  • Avelumab demonstrates potential as a therapeutic option for gastric cancer.
  • Further clinical investigation is warranted to establish its role in GC treatment.
  • Combination strategies involving avelumab may offer improved outcomes for GC patients.
Keywords:
avelumabgastric cancerimmunotherapy

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