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Advanced Glycation End Products in Chinese Medicine Mediated Aging Diseases: A Review

Wenqian Zhang1, Tingting Zhao1, Yonghua Zhao1,2

  • 1Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macao SAR, China.

Current Vascular Pharmacology
|May 8, 2019
PubMed

Insights

Aging accelerates disease risk, with Advanced Glycation End Products (AGEs) playing a key role. This review explores how Chinese medicines can inhibit AGEs to combat age-related diseases like diabetes and atherosclerosis.

Area of Science:

  • Gerontology and Regenerative Medicine
  • Pharmacology and Toxicology
  • Biochemistry and Molecular Biology

Background:

  • Global aging population presents significant health challenges.
  • Increased incidence of age-related diseases like diabetes and atherosclerosis.
  • Advanced Glycation End Products (AGEs) are increasingly implicated in the aging process.

Purpose of the Study:

  • To systematically review the effects of Chinese medicines on inhibiting AGEs.
  • To elucidate the potential mechanisms by which Chinese medicines counteract AGEs.
  • To provide insights into therapeutic strategies for AGEs-related aging diseases.

Main Methods:

  • Systematic literature review of studies on Chinese medicines and AGEs.
  • Analysis of research on the biochemical pathways of AGE formation and action.
  • Evaluation of preclinical and clinical data on relevant Chinese herbal medicines.

Main Results:

  • Identification of various Chinese medicines with AGEs-inhibiting properties.
  • Elucidation of mechanisms including antioxidant, anti-inflammatory, and direct AGEs-breaking effects.
  • Evidence suggesting potential benefits for diabetes, atherosclerosis, and other aging-related conditions.

Conclusions:

  • Chinese medicines offer promising therapeutic potential for managing AGEs-related aging diseases.
  • Further research is warranted to validate efficacy and optimize treatment protocols.
  • Integration of traditional medicine knowledge with modern science can advance aging research.
Keywords:
AgingAlzheimer's diseaseChinese medicinesadvanced glycation end productsdiabetesvascular diseases.

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