Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

2.0K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
2.0K
Viral Mutations00:36

Viral Mutations

39.8K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
39.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vaccination coverage and serological follow-up in children with rheumatologic diseases: a retrospective single-centre study.

Pediatric rheumatology online journal·2026
Same author

Pulmonary surveillance in inborn errors of immunity: current challenges and emerging approaches.

Frontiers in immunology·2026
Same author

Human germline biallelic loss-of-function <i>OSMR</i> variants cause severe allergic disease.

Journal of human immunity·2026
Same author

Primary atopic disorders: Monogenic insights into immunity.

Journal of human immunity·2026
Same author

Serological immunity against vaccine-preventable diseases in children with inflammatory bowel disease at diagnosis.

JPGN reports·2026
Same author

Attenuation of cGAS-STING signaling-mediated lung inflammation during infection through autophagy induction by bioactive nanodevices.

Theranostics·2026

Related Experiment Video

Updated: Jan 25, 2026

Computational Analysis of the Caenorhabditis elegans Germline to Study the Distribution of Nuclei, Proteins, and the Cytoskeleton
08:01

Computational Analysis of the Caenorhabditis elegans Germline to Study the Distribution of Nuclei, Proteins, and the Cytoskeleton

Published on: April 19, 2018

6.8K

Germline CBM-opathies: From immunodeficiency to atopy.

Henry Y Lu1, Catherine M Biggs1, Geraldine Blanchard-Rohner2

  • 1Department of Pediatrics, British Columbia Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada; Experimental Medicine Program, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

The Journal of Allergy and Clinical Immunology
|May 8, 2019
PubMed
Summary

Germline mutations in CBM complex genes (CARD9, CARD11, CARD14, BCL10, MALT1) cause CBM-opathies, a spectrum of immune disorders. This review details CBM complex biology, clinical phenotypes, and management strategies.

Keywords:
BCL10CARD11CARD14CARD9CBM-opathiesMALT1combined immunodeficiencycongenital B-cell lymphocytosisprimary atopic diseaseprimary immunodeficiencies

More Related Videos

Comprehensive Assessment of Germline Chemical Toxicity Using the Nematode Caenorhabditis elegans
10:55

Comprehensive Assessment of Germline Chemical Toxicity Using the Nematode Caenorhabditis elegans

Published on: February 22, 2015

8.5K
In Situ Detection of Ribonucleoprotein Complex Assembly in the C. elegans Germline using Proximity Ligation Assay
08:56

In Situ Detection of Ribonucleoprotein Complex Assembly in the C. elegans Germline using Proximity Ligation Assay

Published on: May 5, 2020

6.3K

Related Experiment Videos

Last Updated: Jan 25, 2026

Computational Analysis of the Caenorhabditis elegans Germline to Study the Distribution of Nuclei, Proteins, and the Cytoskeleton
08:01

Computational Analysis of the Caenorhabditis elegans Germline to Study the Distribution of Nuclei, Proteins, and the Cytoskeleton

Published on: April 19, 2018

6.8K
Comprehensive Assessment of Germline Chemical Toxicity Using the Nematode Caenorhabditis elegans
10:55

Comprehensive Assessment of Germline Chemical Toxicity Using the Nematode Caenorhabditis elegans

Published on: February 22, 2015

8.5K
In Situ Detection of Ribonucleoprotein Complex Assembly in the C. elegans Germline using Proximity Ligation Assay
08:56

In Situ Detection of Ribonucleoprotein Complex Assembly in the C. elegans Germline using Proximity Ligation Assay

Published on: May 5, 2020

6.3K

Area of Science:

  • Immunology
  • Genetics
  • Molecular Biology

Background:

  • Caspase recruitment domain (CARD) protein-B cell CLL/lymphoma 10 (BCL10)-MALT1 paracaspase (MALT1) [CBM] complexes are crucial signaling adaptors in immune and inflammatory responses.
  • Germline mutations in CBM complex genes lead to CBM-opathies, presenting diverse clinical phenotypes from immunodeficiency to lymphocytosis.

Purpose of the Study:

  • To review key discoveries in CBM complex biology.
  • To provide an overview of the clinical spectrum, diagnosis, and treatment of CBM-opathies.

Main Methods:

  • Literature review of CBM complex biology and CBM-opathies.
  • Synthesis of clinical data on patients with germline mutations in CARD9, CARD11, CARD14, BCL10, and MALT1.

Main Results:

  • CBM complexes integrate signals from various receptors, impacting immune responses.
  • CBM-opathies exhibit a rapidly expanding and heterogeneous clinical spectrum.
  • Germline mutations in CARD9, CARD11, CARD14, BCL10, and MALT1 are associated with distinct clinical presentations.

Conclusions:

  • Understanding CBM complex function is vital for diagnosing and managing CBM-opathies.
  • A comprehensive approach to clinical presentation, diagnostics, and treatment is necessary for patients with CBM-opathies.