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B7-H3 and its role in bone cancers
1Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Department of Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Pathology, Research and Practice
|May 8, 2019
Summary
B7-H3 is a promising target for bone cancer immunotherapy. Research shows its potential in osteosarcoma and myeloma, with ongoing clinical trials exploring B7-H3 targeted therapies for improved outcomes.
Area of Science:
- Oncology
- Immunotherapy
- Molecular Biology
Background:
- Bone cancers often exhibit high metastasis and recurrence rates, necessitating novel therapeutic strategies beyond conventional treatments.
- While checkpoint immunotherapies show promise, the role of B7-H3 (CD276), a B7-family molecule, remains underexplored in bone malignancies.
- Existing treatments for bone cancers have limitations, creating an urgent need for innovative and effective therapeutic approaches.
Purpose of the Study:
- To review and summarize current research on the expression and therapeutic targeting of B7-H3 in various bone cancers.
- To identify the unmet needs and potential of B7-H3 as a novel immunotherapeutic target in bone oncology.
Main Methods:
- Literature review of studies investigating B7-H3 expression in osteosarcoma, chondrosarcoma, Ewing's sarcoma, myeloma, osteoclastoma, and chordoma.
- Analysis of research exploring B7-H3 targeted immunotherapies, including chimeric antigen receptor (CAR) T-cells and antibody-based treatments.
- Inclusion of data from preclinical studies and ongoing clinical trials evaluating B7-H3 as a therapeutic target.
Main Results:
- B7-H3 expression has been investigated in osteosarcoma, myeloma, osteoclastoma, and chordoma, with limited research in chondrosarcoma.
- Preclinical studies demonstrate the potential of targeting B7-H3 using CAR T-cells and antibodies in Ewing's sarcoma and myeloma.
- Two clinical trials are currently underway to evaluate B7-H3 as a therapeutic target in osteosarcoma and myeloma.
Conclusions:
- B7-H3 represents a potential therapeutic target for several types of bone cancer.
- Further research and clinical investigation are warranted to fully elucidate the role of B7-H3 in bone cancer and its therapeutic efficacy.
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