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Published on: April 12, 2011
Population Pharmacokinetics of Anidulafungin in Critically Ill Patients
S Luque1,2,3,4,5, W Hope4,6, N Campillo7,2
1Pharmacy Department, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain sluque@parcdesalutmar.cat.
Abstract:
A two-compartment pharmacokinetic (PK) population model of anidulafungin was fitted to PK data from 23 critically ill patients (age, 65 years [range, 28 to 81 years]; total body weight [TBW], 75 kg [range, 54 to 168 kg]). TBW was associated with clearance and incorporated into a final population PK model. Simulations suggested that patients with higher TBWs had less-extensive MIC coverage. Dosage escalation may be warranted in patients with high TBWs to ensure optimal drug exposures for treatment of Candida albicans and Candida glabrata infections.
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