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Updated: Jan 25, 2026

Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers
Published on: July 21, 2017
An eximious and affordable GSH stimulus-responsive poly(α-lipoic acid) nanocarrier bonding combretastatin A4 for
Zhilin Liu1, Na Shen, Zhaohui Tang
1Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China. xschen@ciac.ac.cn.
Abstract:
Due to poor penetration of cytotoxic-drug-loaded-nanomedicines, more and more attention has been paid to nanodrugs of vascular disrupting agents (VDAs). However, traditional VDA nanodrugs lack tumor-selectivity, so new nano-carriers for tumor-selective CA4 delivery are urgently needed. Here, a novel PEGylated poly(alpha-lipoic acid) graft combretastatin A4 (PALA-g-mPEG/CA4) nanoparticle with glutathione (GSH) stimulus responsive ability was prepared from alpha-lipoic acid in a simple approach, which can accumulate and release CA4 selectively in a tumor site. Furthermore, this simple system has potential application value for tumor-targeting delivery and GSH sensitive release of other drugs.
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